Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization.
about
Structural determinants and mechanism of HIV-1 genome packagingIs HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?Cation-dependent cleavage of the duplex form of the subtype-B HIV-1 RNA dimerization initiation siteThe Life-Cycle of the HIV-1 Gag-RNA ComplexRNA trafficking signals in human immunodeficiency virus type 1.Elucidation and characterization of oligonucleotide-accessible sites on HIV-2 leader region RNA.Delineation of the preferences and requirements of the human immunodeficiency virus type 1 dimerization initiation signal by using an in vivo cell-based selection approach.Studies of the genomic RNA of leukosis viruses: implications for RNA dimerization.trans-encapsidation of a poliovirus replicon by different picornavirus capsid proteins.HIV-1 DIS stem loop forms an obligatory bent kissing intermediate in the dimerization pathway.Mutations within four distinct gag proteins are required to restore replication of human immunodeficiency virus type 1 after deletion mutagenesis within the dimerization initiation site.Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral RNAEffects of a single amino acid substitution within the p2 region of human immunodeficiency virus type 1 on packaging of spliced viral RNAOptimal packaging of FIV genomic RNA depends upon a conserved long-range interaction and a palindromic sequence within gagSequence requirement for hand-in-hand interaction in formation of RNA dimers and hexamers to gear phi29 DNA translocation motor.Dimerization of HIV-1 genomic RNA of subtypes A and B: RNA loop structure and magnesium bindingInhibition of 5'-UTR RNA conformational switching in HIV-1 using antisense PNAs.Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions.Structural basis of genomic RNA (gRNA) dimerization and packaging determinants of mouse mammary tumor virus (MMTV).The dimer initiation sequence stem-loop of human immunodeficiency virus type 1 is dispensable for viral replication in peripheral blood mononuclear cells.SHAPE analysis of the FIV Leader RNA reveals a structural switch potentially controlling viral packaging and genome dimerization.HIV-2 genome dimerization is required for the correct processing of Gag: a second-site reversion in matrix can restore both processes in dimerization-impaired mutant virusesA proposal for a new HIV-1 DLS structural model.A proton-coupled dynamic conformational switch in the HIV-1 dimerization initiation site kissing complex.Mechanism of enhanced mechanical stability of a minimal RNA kissing complex elucidated by nonequilibrium molecular dynamics simulationsPrimary T-lymphocytes rescue the replication of HIV-1 DIS RNA mutants in part by facilitating reverse transcription.Fluorescent HIV-1 Dimerization Initiation Site: design, properties, and use for ligand discoveryRandomization and in vivo selection reveal a GGRG motif essential for packaging human immunodeficiency virus type 2 RNAMechanism of HIV-1 RNA dimerization in the central region of the genome and significance for viral evolution.mRNA molecules containing murine leukemia virus packaging signals are encapsidated as dimers.Structural dynamics of retroviral genome and the packagingA short sequence motif in the 5' leader of the HIV-1 genome modulates extended RNA dimer formation and virus replication.Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging.Moloney murine sarcoma virus genomic RNAs dimerize via a two-step process: a concentration-dependent kissing-loop interaction is driven by initial contact between consecutive guanines.Compensatory point mutations in the human immunodeficiency virus type 1 Gag region that are distal from deletion mutations in the dimerization initiation site can restore viral replicationBinding of the human immunodeficiency virus type 1 Gag protein to the viral RNA encapsidation signal in the yeast three-hybrid system.Recombination in the 5' leader of murine leukemia virus is accurate and influenced by sequence identity with a strong bias toward the kissing-loop dimerization region.Sequences in pol are required for transfer of human foamy virus-based vectors.Functional analysis of the core human immunodeficiency virus type 1 packaging signal in a permissive cell line.Mutations of the kissing-loop dimerization sequence influence the site specificity of murine leukemia virus recombination in vivo.
P2860
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P2860
Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Mutations in the kissing-loop ...... NA packaging and dimerization.
@ast
Mutations in the kissing-loop ...... NA packaging and dimerization.
@en
type
label
Mutations in the kissing-loop ...... NA packaging and dimerization.
@ast
Mutations in the kissing-loop ...... NA packaging and dimerization.
@en
prefLabel
Mutations in the kissing-loop ...... NA packaging and dimerization.
@ast
Mutations in the kissing-loop ...... NA packaging and dimerization.
@en
P2093
P2860
P1433
P1476
Mutations in the kissing-loop ...... NA packaging and dimerization.
@en
P2093
P2860
P304
P407
P577
1997-05-01T00:00:00Z