Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.
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Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by DaxxHuman MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.Adenovirus E1B 55K represses p53 activation in vitro.Antiviral actions of interferonsRBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteinsAdenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cellsDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexMechanisms of pathogenesis of emerging adenoviruses.p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent mannerAnalysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexSUMO-1 modification required for transformation by adenovirus type 5 early region 1B 55-kDa oncoproteinAdenovirus E1B 55-kilodalton oncoprotein inhibits p53 acetylation by PCAF.Sequestration of p53 in the cytoplasm by adenovirus type 12 E1B 55-kilodalton oncoprotein is required for inhibition of p53-mediated apoptosis.The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence.The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication.Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism.Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.Inhibition of p53 by adenovirus type 12 E1B-55K deregulates cell cycle control and sensitizes tumor cells to genotoxic agentsAdenovirus replaces mitotic checkpoint controls.Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells.Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival.Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.Aggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substratesThe adenoviral E1B 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription.Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation.Innate immunity to adenovirus.Dual Role of p53 in Innate Antiviral Immunity.Role of E1B55K in E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes.The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2.Corepressor required for adenovirus E1B 55,000-molecular-weight protein repression of basal transcription.The E4orf6/E1B55K E3 ubiquitin ligase complexes of human adenoviruses exhibit heterogeneity in composition and substrate specificity.Caspase cleavage of the nonstructural protein NS1 mediates replication of Aleutian mink disease parvovirus.A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite.Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein.Adenovirus type 5 early region 1B 156R protein promotes cell transformation independently of repression of p53-stimulated transcription.
P2860
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P2860
Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Regulation of p53-dependent ap ...... in of human adenovirus type 5.
@ast
Regulation of p53-dependent ap ...... in of human adenovirus type 5.
@en
type
label
Regulation of p53-dependent ap ...... in of human adenovirus type 5.
@ast
Regulation of p53-dependent ap ...... in of human adenovirus type 5.
@en
prefLabel
Regulation of p53-dependent ap ...... in of human adenovirus type 5.
@ast
Regulation of p53-dependent ap ...... in of human adenovirus type 5.
@en
P2860
P1433
P1476
Regulation of p53-dependent ap ...... in of human adenovirus type 5.
@en
P2093
Branton PE
Teodoro JG
P2860
P304
P407
P577
1997-05-01T00:00:00Z