Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64
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Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells.Diminished reovirus capsid stability alters disease pathogenesis and littermate transmissionAvian Reoviruses Cause Apoptosis in Cultured Cells: Viral Uncoating, but Not Viral Gene Expression, Is Required for Apoptosis InductionStructure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.Apoptosis induction influences reovirus replication and virulence in newborn miceEMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virusDeterminants of strain-specific differences in efficiency of reovirus entryRequirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide.Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells.Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domainCleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck.Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3.The reovirus S4 gene 3' nontranslated region contains a translational operator sequence.A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance.Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3.Virion disassembly is required for apoptosis induced by reovirus.A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure.Caspase-3 activation is required for reovirus-induced encephalitis in vivo.Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection.Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane.Impact of host proteases on reovirus infection in the respiratory tract.Molecular determinants of proteolytic disassembly of the reovirus outer capsid.Thermostabilizing mutations in reovirus outer-capsid protein mu1 selected by heat inactivation of infectious subvirion particles.Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.Thermolabilizing pseudoreversions in reovirus outer-capsid protein micro 1 rescue the entry defect conferred by a thermostabilizing mutation.A chaperone-activated nonenveloped virus perforates the physiologically relevant endoplasmic reticulum membrane.From touchdown to transcription: the reovirus cell entry pathwayReovirus receptors, cell entry, and proapoptotic signaling.NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry.The oncolytic effect in vivo of reovirus on tumour cells that have survived reovirus cell killing in vitro.A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.Structural Insights into Reovirus σ1 Interactions with Two Neutralizing Antibodies.Lipid Membranes Facilitate Conformational Changes Required for Reovirus Cell Entry.Lipids Cooperate with the Reovirus Membrane Penetration Peptide to Facilitate Particle Uncoating.Optimum length and flexibility of reovirus attachment protein σ1 are required for efficient viral infection.Reovirus virion-like particles obtained by recoating infectious subvirion particles with baculovirus-expressed sigma3 protein: an approach for analyzing sigma3 functions during virus entry.In vitro recoating of reovirus cores with baculovirus-expressed outer-capsid proteins mu1 and sigma3.Protease cleavage of reovirus capsid protein mu1/mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle.
P2860
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P2860
Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Mutations in reovirus outer-ca ...... ance to protease inhibitor E64
@ast
Mutations in reovirus outer-ca ...... ance to protease inhibitor E64
@en
type
label
Mutations in reovirus outer-ca ...... ance to protease inhibitor E64
@ast
Mutations in reovirus outer-ca ...... ance to protease inhibitor E64
@en
prefLabel
Mutations in reovirus outer-ca ...... ance to protease inhibitor E64
@ast
Mutations in reovirus outer-ca ...... ance to protease inhibitor E64
@en
P2860
P1433
P1476
Mutations in reovirus outer-ca ...... ance to protease inhibitor E64
@en
P2093
P2860
P304
P407
P577
1997-07-01T00:00:00Z