MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain.
about
MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addictionRepressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal deathNovel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes.Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.Circadian cycle-dependent MeCP2 and brain chromatin changesThe genetic and epigenetic journey of embryonic stem cells into mature neural cells.Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulationImpaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domainInterindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD.Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin associationThe characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatinFrom Function to Phenotype: Impaired DNA Binding and Clustering Correlates with Clinical Severity in Males with Missense Mutations in MECP2.The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site.Rett syndrome: a complex disorder with simple roots.Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines.Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization.Ethanol deregulates Mecp2/MeCP2 in differentiating neural stem cells via interplay between 5-methylcytosine and 5-hydroxymethylcytosine at the Mecp2 regulatory elements.MeCP2 and CTCF: enhancing the cross-talk of silencers.Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity.MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.
P2860
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P2860
MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
MeCP2 binds to nucleosome free ...... ated nucleosomes in the brain.
@ast
MeCP2 binds to nucleosome free ...... ated nucleosomes in the brain.
@en
type
label
MeCP2 binds to nucleosome free ...... ated nucleosomes in the brain.
@ast
MeCP2 binds to nucleosome free ...... ated nucleosomes in the brain.
@en
prefLabel
MeCP2 binds to nucleosome free ...... ated nucleosomes in the brain.
@ast
MeCP2 binds to nucleosome free ...... ated nucleosomes in the brain.
@en
P2093
P2860
P356
P1476
MeCP2 binds to nucleosome free ...... ated nucleosomes in the brain.
@en
P2093
Anita A Thambirajah
Begonia Silva-Moreno
Brent E Gowen
Christoph H Borchers
Evgeniy V Petrotchenko
Frank Lutz
J Adam Hall
Jason J Serpa
Juan Ausió
P2860
P304
P356
10.1093/NAR/GKR1066
P407
P577
2011-12-05T00:00:00Z