Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. - Wikidata - wikimedia - TriplyDB

Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.

Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.

http://www.wikidata.org/entity/Q35894811

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Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects Out of balance: R-loops in human disease Replication Stress: A Lifetime of Epigenetic Change Snaps and mends: DNA breaks and chromosomal translocations Mechanisms of genome instability induced by RNA-processing defects.Sus1p facilitates pre-initiation complex formation at the SAGA-regulated genes independently of histone H2B de-ubiquitylation Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination.Epigenetic Alterations in Fanconi Anaemia: Role in Pathophysiology and Therapeutic Potential.RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation.A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.R-loops and genomic instability in Bre1 (RNF20/40)-deficient cells.RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.Functional analysis of Bre1p, an E3 ligase for histone H2B ubiquitylation, in regulation of RNA polymerase II association with active genes and transcription in vivo Chromatin: receiver and quarterback for cellular signals Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.Histone modifications as regulators of life and death in Saccharomyces cerevisiae The enigmatic role of H2Bub1 in cancer.The potential role of O-GlcNAc modification in cancer epigenetics.The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.Mitotic accumulation of dimethylated lysine 79 of histone H3 is important for maintaining genome integrity during mitosis in human cells.R Loops and Links to Human Disease.Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function.Loss of H2Bub1 Expression is Linked to Poor Prognosis in Nodal Negative Colorectal Cancers.RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression.Transcriptional stimulatory and repressive functions of histone H2B ubiquitin ligase.let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery.Testicular cancer from diagnosis to epigenetic factors.Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma.Centromeric histone H2B monoubiquitination promotes noncoding transcription and chromatin integrity.Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress.

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Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.

http://www.wikidata.org/entity/Q35894811

description

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2012年の論文

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2012年論文

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name

Deficiency in mammalian histon ...... s and chromosomal instability.

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Deficiency in mammalian histon ...... s and chromosomal instability.

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type

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Deficiency in mammalian histon ...... s and chromosomal instability.

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Deficiency in mammalian histon ...... s and chromosomal instability.

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Deficiency in mammalian histon ...... s and chromosomal instability.

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Deficiency in mammalian histon ...... s and chromosomal instability.

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0008-5472.CAN-11-2209

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Cancer Research

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Deficiency in mammalian histon ...... s and chromosomal instability.

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Brock J Sishc

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Diana A Chernikova

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J Martin Brown

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James D Brooks

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Jennifer A Dorth

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John C Game

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John P Higgins

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Monica Nicolau

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Olga V Razorenova

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Shirley Kwok

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P2860

CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis.

Role for the silencing protein Dot1 in meiotic checkpoint control.

The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18

TRF2 Protects Human Telomeres from End-to-End Fusions

The human and mouse replication-dependent histone genes

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2111-2119

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scholarly article

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10.1158/0008-5472.CAN-11-2209

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8

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72

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2012-02-21T00:00:00Z

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22354749

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3328627

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