The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors.
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Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vectorDifferential activation of innate immune responses by adenovirus and adeno-associated virus vectorsPreclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model systemSPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131IReal-time dynamic imaging of virus distribution in vivoAdenovirus Binding to Blood Factors Results in Liver Cell Infection and HepatotoxicityThe transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogensGammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk.Selection of muscle-binding peptides from context-specific peptide-presenting phage libraries for adenoviral vector targeting.Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.Comparison of replication-competent, first generation, and helper-dependent adenoviral vaccinesSafety Studies in Tumor and Non-Tumor-Bearing Mice in Support of Clinical Trials Using Oncolytic VSV-IFNβ-NIS.A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expressionAdenoviral vector immunity: its implications and circumvention strategies.Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic AdenovirusIn vivo stable transduction of humanized liver tissue in chimeric mice via high-capacity adenovirus-lentivirus hybrid vector.Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactionsRedundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver.Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment.Hepatic gene transfer as a means of tolerance induction to transgene productsBiodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging.Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathwayImplication of interfering antibody formation and apoptosis as two different mechanisms leading to variable duration of adenovirus-mediated transgene expression in immune-competent mice.Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene.Generation of adenovirus vectors devoid of all viral genes by recombination between inverted repeatsVariation in adenovirus transgene expression between BALB/c and C57BL/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activationReducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactionsAdenovirus infection results in alterations of insulin signaling and glucose homeostasis.TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection.Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activationSafety studies on intravenous administration of oncolytic recombinant vesicular stomatitis virus in purpose-bred beagle dogs.Recognition of virus infection and innate host responses to viral gene therapy vectors.Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein.Development of a targeted gene vector platform based on simian adenovirus serotype 24.Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.Evaluation of biodistribution and safety of adenovirus vectors containing group B fibers after intravenous injection into baboons.Redox regulation of adenovirus-induced AP-1 activation by overexpression of manganese-containing superoxide dismutase.Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review)Multiple innate immune pathways contribute to the immunogenicity of recombinant adenovirus vaccine vectors
P2860
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P2860
The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The role of Kupffer cell activ ...... ecombinant adenovirus vectors.
@ast
The role of Kupffer cell activ ...... ecombinant adenovirus vectors.
@en
type
label
The role of Kupffer cell activ ...... ecombinant adenovirus vectors.
@ast
The role of Kupffer cell activ ...... ecombinant adenovirus vectors.
@en
prefLabel
The role of Kupffer cell activ ...... ecombinant adenovirus vectors.
@ast
The role of Kupffer cell activ ...... ecombinant adenovirus vectors.
@en
P2093
P2860
P1433
P1476
The role of Kupffer cell activ ...... recombinant adenovirus vectors
@en
P2093
D Schowalter
I Kirillova
P2860
P304
P407
P577
1997-11-01T00:00:00Z