Disruption of protein quality control in Parkinson's disease.
about
Glucocerebrosidase is shaking up the synucleinopathiesOxidative stress and Parkinson's diseasePhosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseThe BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.On the Relationship between Energy Metabolism, Proteostasis, Aging and Parkinson's Disease: Possible Causative Role of Methylglyoxal and Alleviative Potential of Carnosine.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesMutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathologyTranscriptional regulation by nicotine in dopaminergic neurons.Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments.Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression.Comparison of the structure, function and autophagic maintenance of mitochondria in nigrostriatal and tuberoinfundibular dopamine neurons.Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective AutophagyToxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell ModelsGBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Parkin Protects against Oxygen-Glucose Deprivation/Reperfusion Insult by Promoting Drp1 Degradation.RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis.Protein misfolding in neurodegenerative diseases: implications and strategies.Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.Advances in the genetics of Parkinson disease.Emerging role of autophagy in pediatric neurodegenerative and neurometabolic diseases.The pathomechanisms underlying Parkinson's disease.Proteostasis in endoplasmic reticulum--new mechanisms in kidney disease.The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism.Mitochondrial Quality Control Proteases in Neuronal Welfare.BAG1 is neuroprotective in in vivo and in vitro models of Parkinson's disease.Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells.Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases.HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B.Progress toward an integrated understanding of Parkinson's disease.The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators.Decreased proteasomal activity causes photoreceptor degeneration in miceBeclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells.The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation.
P2860
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P2860
Disruption of protein quality control in Parkinson's disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Disruption of protein quality control in Parkinson's disease.
@ast
Disruption of protein quality control in Parkinson's disease.
@en
type
label
Disruption of protein quality control in Parkinson's disease.
@ast
Disruption of protein quality control in Parkinson's disease.
@en
prefLabel
Disruption of protein quality control in Parkinson's disease.
@ast
Disruption of protein quality control in Parkinson's disease.
@en
P2860
P1476
Disruption of protein quality control in Parkinson's disease.
@en
P2093
Caroline Stetler
Casey Cook
P2860
P304
P356
10.1101/CSHPERSPECT.A009423
P577
2012-05-01T00:00:00Z