Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition
about
Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2)Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cellsStructure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agentsIn vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazolesComparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model.In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida sppAnti-Pneumocystis activities of aromatic diamidoxime prodrugs.Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulationsMolecular characterization of recombinant Pneumocystis carinii topoisomerase I: differential interactions with human topoisomerase I poisons and pentamidine.Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds.Marked antigiardial activity of Yucca baccata extracts: a potential natural alternative for treating protozoan infectionsCharacterization of a novel DNA minor-groove complex.Phosphonoxins III: synthesis of α-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activityIn vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].Aromatic diamidines as antiparasitic agents.Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.Anti-Pneumocystis carinii pneumonia activity of dicationic 2,4-diarylpyrimidines.The Application of DNA-Biosensors and Differential Scanning Calorimetry to the Study of the DNA-Binding Agent BerenilSynthesis of dicationic diarylpyridines as nucleic-acid binding agents.Identification and characterization of an endo/exonuclease in Pneumocystis carinii that is inhibited by dicationic diarylfurans with efficacy against Pneumocystis pneumonia.Synthesis of dicationic diaryltriazines nucleic acid binding agents.Sequence-dependent binding of bis-amidine carbazole dications to DNA.Evaluation of silymarin in the treatment on asymptomatic Giardia infections in dogs.Efficient estimation of MMGBSA-based BEs for DNA and aromatic furan amidino derivatives.Identification, characteristic and phylogenetic analysis of type II DNA topoisomerase gene in Giardia lamblia.
P2860
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P2860
Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Structure-activity studies of ...... al topoisomerase II inhibition
@ast
Structure-activity studies of ...... al topoisomerase II inhibition
@en
type
label
Structure-activity studies of ...... al topoisomerase II inhibition
@ast
Structure-activity studies of ...... al topoisomerase II inhibition
@en
prefLabel
Structure-activity studies of ...... al topoisomerase II inhibition
@ast
Structure-activity studies of ...... al topoisomerase II inhibition
@en
P2093
P2860
P356
P1476
Structure-activity studies of ...... al topoisomerase II inhibition
@en
P2093
P2860
P304
P356
10.1128/AAC.37.12.2668
P407
P577
1993-12-01T00:00:00Z