The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component.
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PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.Cell signaling by receptor tyrosine kinasesRaf kinases in cancer-roles and therapeutic opportunitiesNetwork Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.Ultrasonic bioreactor as a platform for studying cellular response.An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generationTDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.Raf-1 activation prevents caspase 9 processing downstream of apoptosome formation.Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma.An in vitro multistep carcinogenesis model for both HPV-positive and -negative human oral squamous cell carcinomasSignaling in cell differentiation and morphogenesisAn integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumorsMapping the molecular determinants of BRAF oncogene dependence in human lung cancer.A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor.Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancerAn integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.Polyisoprenylated cysteinyl amide inhibitors induce caspase 3/7- and 8-mediated apoptosis and inhibit migration and invasion of metastatic prostate cancer cells.Raf-1 regulates Rho signaling and cell migration.Regulation of cellular proliferation, differentiation and cell death by activated Raf.Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice.Lysophosphatidic acid (LPA) stimulates mouse mammary epithelial cell growth.
P2860
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P2860
The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The transcriptional response t ...... s a major autocrine component.
@ast
The transcriptional response t ...... s a major autocrine component.
@en
type
label
The transcriptional response t ...... s a major autocrine component.
@ast
The transcriptional response t ...... s a major autocrine component.
@en
prefLabel
The transcriptional response t ...... s a major autocrine component.
@ast
The transcriptional response t ...... s a major autocrine component.
@en
P2093
P2860
P356
P1476
The transcriptional response t ...... s a major autocrine component.
@en
P2093
Barbara Nicke
Patricia H Warne
Simon Tomlinson
P2860
P304
P356
10.1091/MBC.E03-11-0807
P577
2004-04-16T00:00:00Z