Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. - Wikidata - wikimedia - TriplyDB

Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.

Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.

http://www.wikidata.org/entity/Q35927959

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Tuberculosis vaccines: beyond bacille Calmette-Guerin Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers Tuberculosis vaccines and prevention of infection Immune vulnerability of infants to tuberculosis Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis Systems biology in vaccine design Vaccines against tuberculosis: where are we and where do we need to go?Prime-boost approaches to tuberculosis vaccine development Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo Mycobacterium bovis Infection of Cattle and White-Tailed Deer: Translational Research of Relevance to Human Tuberculosis Quest for correlates of protection against tuberculosis Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis Novel vaccination strategies against tuberculosis.Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model Mycobacterial PE/PPE proteins at the host-pathogen interface.Cellular immune responses to nine Mycobacterium tuberculosis vaccine candidates following intranasal vaccination.Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations.Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice.Immunization of mice with a recombinant adenovirus vaccine inhibits the early growth of Mycobacterium tuberculosis after infection Immunological memory transferred with CD4 T cells specific for tuberculosis antigens Ag85B-TB10.4: persisting antigen enhances protection.Polyclonal activation of naïve T cells by urease deficient-recombinant BCG that produced protein complex composed of heat shock protein 70, CysO and major membrane protein-II Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin Non-tuberculous mycobacteria have diverse effects on BCG efficacy against Mycobacterium tuberculosis.Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice Role of 4-1BB receptor in the control played by CD8(+) T cells on IFN-gamma production by Mycobacterium tuberculosis antigen-specific CD4(+) T Cells Systemic BCG immunization induces persistent lung mucosal multifunctional CD4 T(EM) cells which expand following virulent mycobacterial challenge The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults.Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis.CD4 and CD8 T-cell responses to mycobacterial antigens in African children BCG induces protection against Mycobacterium tuberculosis infection in the Wistar rat model.Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS.Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis.Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth.A new recombinant BCG vaccine induces specific Th17 and Th1 effector cells with higher protective efficacy against tuberculosis.

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P2860

Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.

http://www.wikidata.org/entity/Q35927959

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Proceedings of the National Academy of Sciences of the United States of America

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Poor correlation between BCG v ...... otection against tuberculosis.

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Anne Köhler

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Delia Miekley

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Doris Lazar

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Hans-Willi Mittrücker

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Marion Krause

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Peggy Mex

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P2860

Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity

Mycobacterium bovis BCG induces similar immune responses and protection by rectal and parenteral immunization routes.

Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice.

Macrophage activation and resistance to pulmonary tuberculosis

Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice.

Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis.

CD8(+) T cells participate in the memory immune response to Mycobacterium tuberculosis.

Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein.

Lymphocyte recruitment and protective efficacy against pulmonary mycobacterial infection are independent of the route of prior Mycobacterium bovis BCG immunization.

BCG: the challenge continues.

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104

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Stefan Kaufmann

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6197546

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