STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
about
Building a ninefold symmetrical barrel: structural dissections of centriole assemblyThe PLK4-STIL-SAS-6 module at the core of centriole duplicationFAM46 proteins are novel eukaryotic non-canonical poly(A) polymerasesTargeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancerProtein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication.The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans.CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole BiogenesisDrosophila Ana1 is required for centrosome assembly and centriole elongation.Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging.Role of primary cilia in non-dividing and post-mitotic cells.Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis.Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.Building the right centriole for each cell type.Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis.PLK4: a link between centriole biogenesis and cancer.STIL balancing primary microcephaly and cancer.Once and only once: mechanisms of centriole duplication and their deregulation in disease.PLK4 phosphorylation of CP110 is required for efficient centriole assembly.A homeostatic clock sets daughter centriole size in flies.An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.Abnormally high expression of POLD1, MCM2, and PLK4 promotes relapse of acute lymphoblastic leukemia.Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network
P2860
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P2860
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
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name
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
@ast
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
@en
type
label
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
@ast
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
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prefLabel
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
@ast
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
@en
P2093
P2860
P356
P1433
P1476
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
@en
P2093
Anna-Maria Gabryjonczyk
Christian Arquint
Evelyn Sauer
Raphael Böhm
Sebastian Hiller
Stefan Imseng
Timm Maier
P2860
P356
10.7554/ELIFE.07888
P407
P50
P577
2015-07-18T00:00:00Z