Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome
about
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its deathA single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chainsStructure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targetsSubstrate Ubiquitination Controls the Unfolding Ability of the Proteasome.The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle ProgressionUbiquitin-like domains can target to the proteasome but proteolysis requires a disordered region.Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29.Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.Structure of the human 26S proteasome at a resolution of 3.9 Å.Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.Structural insights into the functional cycle of the ATPase module of the 26S proteasome.Phospholipase Lpl1 links lipid droplet function with quality control protein degradation.Reversible phosphorylation of the 26S proteasome.Tuning the proteasome to brighten the end of the journey.Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae.High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx.Ubiquitin recognition by the proteasome.Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal.The Logic of the 26S Proteasome.Proteasome Structure and Assembly.AAA-ATPases in Protein Degradation.(1)H, (15)N, (13)C resonance assignments for Saccharomyces cerevisiae Rad23 UBL domain.Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis.Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.Meddling with Fate: The Proteasomal Deubiquitinating Enzymes.Ligand binding and conformational dynamics in a flavin-based electron-bifurcating enzyme complex revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment.Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease.TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14.Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease.Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug repositionStructure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4
P2860
Q26738549-6F228DD1-BFB7-4349-83F2-8FED86778509Q28910344-D5353EBD-2E1E-4C23-98C4-AD61455E9378Q33862782-B70DA962-4917-42F4-8DB9-3EC7AAF0E9D7Q36074198-46971F90-DF0F-4BF3-A27A-0C0277B2271CQ36884720-6D46E0FF-6A2E-41FE-B738-7B8DEAF30DA8Q36946185-F276DDCD-DD76-4756-B17F-8F4180AD4FB8Q37006187-CE18D504-3A85-468D-9BCA-70E4EEB73423Q37076872-324F3BCB-B967-4CF8-A079-949AD24E669AQ37078653-0CF32870-BCE1-452F-9C20-579FC42B3A0FQ37102327-F609A9BA-EDFB-4DF5-A70C-EA2A2D196055Q37472973-2F25ACB3-DD88-4AAE-AD95-9CFC95E2C1E7Q37640400-6F8F61C7-D25E-4C5A-9B04-8E6129B92378Q37699007-46FFF29F-6475-4CA5-B42B-4D9A7C7DE863Q37712428-78674AC0-BC26-43AE-A07D-EB0CB9987860Q38559265-B5ED4F84-CADC-4A03-AFD1-37FBD509F199Q38741389-1EFF8D19-5373-48E4-BB7E-DD061F75A483Q38966261-60DF3127-43DF-495E-9272-0C6ACBE19320Q39010593-AC4DAE7C-861F-4015-8C6B-7481EC62BEF3Q39077452-4ACBE0EF-678B-4F76-9848-46C1C56AAA96Q39298346-9313FB8A-96D8-4B83-A0CC-C5F082792836Q39318404-796B2059-8777-45DC-A006-1A9663C9D798Q39352782-BC45CA23-E869-44F8-84E6-3FADD58DB950Q39414304-1CC634FD-E08A-4D65-B138-22E1C3F0167FQ39759648-9EC4754D-AF96-4C0B-AC30-6A2A2F9BBCDDQ41546924-BF550D9E-6D19-4A97-88BB-1121E79A7B7DQ41691918-99F7AECE-3048-4C86-AF7F-7ABA38C0B38AQ42377050-E161F13C-291B-4962-B197-CE54732BCD72Q42382149-85612470-3CFD-435F-A3C6-6DB477F401BDQ42508594-E8CA8238-060E-4B93-B95B-8C9513F58DDFQ46188514-3E980E61-B599-488C-B28E-30679451D487Q47292178-E56CE208-0475-4EC5-9F10-4FC1809C6DEFQ48415895-FDFA291F-F933-4A5B-83AF-5AB78FC64212Q49344570-215A68F8-25AA-4001-8EC7-8472346FF3CDQ49484191-9A2579D7-DF45-4709-9239-E896C3AA23CCQ52341015-BA1133D6-2A6B-4439-8DF9-4F0E982FC8A9Q55231947-85F45AAC-A6CD-4E66-B668-B43EA924B780Q57163862-431669CE-3053-4382-B518-A98D38566B31Q57262729-6442B18E-F461-4D26-A98A-5173B3E4D50A
P2860
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Rpn1 provides adjacent recepto ...... iquitination by the proteasome
@ast
Rpn1 provides adjacent recepto ...... iquitination by the proteasome
@en
type
label
Rpn1 provides adjacent recepto ...... iquitination by the proteasome
@ast
Rpn1 provides adjacent recepto ...... iquitination by the proteasome
@en
prefLabel
Rpn1 provides adjacent recepto ...... iquitination by the proteasome
@ast
Rpn1 provides adjacent recepto ...... iquitination by the proteasome
@en
P2093
P2860
P356
P1433
P1476
Rpn1 provides adjacent recepto ...... iquitination by the proteasome
@en
P2093
Bradley B Stocks
Byung-Hoon Lee
Daniel Finley
Fabian Tuebing
Jacob Vannoy
John R Engen
Kylie J Walters
Naixia Zhang
Sergey G Tarasov
P2860
P356
10.1126/SCIENCE.AAD9421
P407
P577
2016-02-01T00:00:00Z