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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

http://www.wikidata.org/entity/Q35941226

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Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.Design and implementation of an FPGA-based timing pulse programmer for pulsed-electron paramagnetic resonance applications Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β-amyloid through activation of SIRT1/Akt1 pathway.Physical properties of polymorphic yeast prion amyloid fibers.Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in amyloid-β(1-16) at physiological pH and its significance.Intrinsic determinants of Aβ(12-24) pH-dependent self-assembly revealed by combined computational and experimental studies.Copper(II)-Mediated Self-Assembly of Hairpin Peptides and Templated Synthesis of CuS Nanowires.Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide.Early stages of amyloid fibril formation studied by liquid-state NMR: the peptide hormone glucagon.Therapeutics for Alzheimer's disease based on the metal hypothesis The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study.Pharmacotherapeutic targets in Alzheimer's disease Copper(II)-bis-histidine coordination structure in a fibrillar amyloid β-peptide fragment and model complexes revealed by electron spin echo envelope modulation spectroscopy Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease.Peptide membranes in chemical evolution.Context dependence of protein misfolding and structural strains in neurodegenerative diseases.Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.Computational insights into the development of novel therapeutic strategies for Alzheimer's disease.New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.Regulation of myocyte enhancer factor-2 transcription factors by neurotoxins Metallostasis and amyloid β-degrading enzymes.The MEF2 family and the brain: from molecules to memory.The role of metal ions in amyloid formation: general principles from model peptides.Peptide self-assembly triggered by metal ions.Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design.Amyloid scaffolds as alternative chlorosomes.Altered microglial copper homeostasis in a mouse model of Alzheimer's disease Catalytic diversity in self-propagating peptide assemblies.Inhibition of Aβ42 peptide aggregation by a binuclear ruthenium(II)-platinum(II) complex: Potential for multi-metal organometallics as anti-amyloid agents.Cu(II) mediates kinetically distinct, non-amyloidogenic aggregation of amyloid-beta peptides.Peptides organized as bilayer membranes.Amino acid based dynamic metal-biomolecule frameworks.Acidic pH retards the fibrillization of human Islet Amyloid Polypeptide due to electrostatic repulsion of histidines.Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.Inclusion body myositis in Alzheimer's disease.Tuning One-Dimensional Nanostructures of Bola-Like Peptide Amphiphiles by Varying the Hydrophilic Amino Acids.Understanding the metal mediated assembly and hydrogel formation of a β-hairpin peptide.Heavy metal ion hydrogelation of a self-assembling peptideviacysteinyl chelation Remodeling Cross-β Nanotube Surfaces with Peptide/Lipid Chimeras

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P2860

Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

http://www.wikidata.org/entity/Q35941226

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

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Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

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PNAS.0702669104

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.

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P2093

Anil K Mehta

http://www.w3.org/2001/XMLSchema#string

Bo Tian

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David G Lynn

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Jacob E Shokes

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James A Simmons

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Jeffrey M Canfield

http://www.w3.org/2001/XMLSchema#string

Jijun Dong

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Kurt Warncke

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Robert A Scott

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W Seth Childers

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P2860

Misfolded CuZnSOD and amyotrophic lateral sclerosis

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

Neuronal activity-dependent cell survival mediated by transcription factor MEF2

Protein folding and misfolding

A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia

Conformational disease

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

Structural model of the amyloid fibril formed by beta(2)-microglobulin #21-31 fragment based on vibrational spectroscopy.

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13313-13318

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10.1073/PNAS.0702669104

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33

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104

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2007-08-08T00:00:00Z

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6152562

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17686982

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metal poisoning

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1948904

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