Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector. - Wikidata - wikimedia - TriplyDB

Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.

Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.

http://www.wikidata.org/entity/Q35943417

about

Targeting the latent reservoir to achieve functional HIV cure Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus Bone Marrow Gene Therapy for HIV/AIDS Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice New generation humanized mice for virus research: comparative aspects and future prospects Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice CD25 preselective anti-HIV vectors for improved HIV gene therapy.Optimized lentiviral vectors for HIV gene therapy: multiplexed expression of small RNAs and inclusion of MGMT(P140K) drug resistance gene R88-APOBEC3Gm Inhibits the Replication of Both Drug-resistant Strains of HIV-1 and Viruses Produced From Latently Infected Cells Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART A quantitative comparison of anti-HIV gene therapy delivered to hematopoietic stem cells versus CD4+ T cells.Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice.BLT humanized mice as a small animal model of HIV infection.Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region A cross-species view on viruses Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1 Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1.Genetic modification of hematopoietic stem cells as a therapy for HIV/AIDS.Creating genetic resistance to HIV.Using TRIM5α as an HIV therapeutic: the alpha gene?Stem cell transplantation in the context of HIV--how can we cure HIV infection?Practical considerations in gene therapy for HIV cure.HIV/AIDS: modified stem cells in the spotlight.Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions.Stem cell gene therapy for HIV: strategies to inhibit viral entry and replication.Cell therapies for treatment of human immunodeficiency virus infection.Recent advances in RNAi-based strategies for therapy and prevention of HIV-1/AIDS.Stem cell-based therapies for HIV/AIDS.Gene transfer of two entry inhibitors protects CD4⁺ T cell from HIV-1 infection in humanized mice.The therapeutic landscape of HIV-1 via genome editing Generation of an HIV resistant T-cell line by targeted "stacking" of restriction factors.RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice.Combinatorial CRISPR-Cas9 and RNA Interference Attack on HIV-1 DNA and RNA Can Lead to Cross-Resistance.Safety and efficacy of a tCD25 preselective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells.A novel approach to block HIV-1 coreceptor CXCR4 in non-toxic manner.False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector.Targeting TRIM5α in HIV Cure Strategies for the CRISPR-Cas9 Era.Cell and Gene Therapy for HIV Cure.

P2860

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P2860

Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.

http://www.wikidata.org/entity/Q35943417

description

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name

Generation of an HIV-1-resista ...... on anti-HIV lentiviral vector.

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Generation of an HIV-1-resista ...... on anti-HIV lentiviral vector.

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Generation of an HIV-1-resista ...... on anti-HIV lentiviral vector.

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Generation of an HIV-1-resista ...... on anti-HIV lentiviral vector.

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Generation of an HIV-1-resista ...... on anti-HIV lentiviral vector.

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Generation of an HIV-1-resista ...... on anti-HIV lentiviral vector.

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Journal of Virology

P1476

Generation of an HIV-1-resista ...... ion anti-HIV lentiviral vector

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P2093

Catherine Nacey

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Gerhard Bauer

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Jeannine McGee

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Jon E Walker

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Joseph S Anderson

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Mehrdad Abedi

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Rachel X Chen

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Richard B Pollard

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P2860

HIV-1 integrase inhibitor resistance and its clinical implications

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain

Preintegration HIV-1 inhibition by a combination lentiviral vector containing a chimeric TRIM5 alpha protein, a CCR5 shRNA, and a TAR decoy.

Antiretroviral resistance during successful therapy of HIV type 1 infection.

RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.

A nucleolar TAR decoy inhibitor of HIV-1 replication.

Complete knockdown of CCR5 by lentiviral vector-expressed siRNAs and protection of transgenic macrophages against HIV-1 infection.

P304

5719-5729

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10.1128/JVI.06300-11

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10

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86

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221684921

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22398281

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3347262

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