Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models.

Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models.

Item
http://www.wikidata.org/entity/Q35944107
Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.Role of systems pharmacology in understanding drug adverse events.Present state and future perspectives of using pluripotent stem cells in toxicology researchModulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade.QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome.Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.In vitro cardiovascular effects of dihydroartemisin-piperaquine combination compared with other antimalarialsIn vitro and in vivo models for testing arrhythmogenesis in drugs.Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes.Human embryonic stem cell-derived cardiomyocytes: drug discovery and safety pharmacology.Predicting drug-induced QT prolongation and torsades de pointes: a review of preclinical endpoint measures.Effects of 4-Aminopyridine on Cloned hERG Channels Expressed in Mammalian Cells.The action potential of the Purkinje fiber: an in vitro model for evaluation of the proarrhythmic potential of cardiac and noncardiac drugs.Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
P2860

Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models.

Item
http://www.wikidata.org/entity/Q35944107
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Preclinical strategies to asse ...... e role of experimental models.
@ast
Preclinical strategies to asse ...... e role of experimental models.
@en
type
label
Preclinical strategies to asse ...... e role of experimental models.
@ast
Preclinical strategies to asse ...... e role of experimental models.
@en
prefLabel
Preclinical strategies to asse ...... e role of experimental models.
@ast
Preclinical strategies to asse ...... e role of experimental models.
@en
P1433
P1476
P2093
P304
P31
P356
P478
P577
P698
P356
P1433
P1476
Preclinical strategies to asse ...... e role of experimental models.
@en
P2093
P304
P31
P356
10.1016/J.JELECTROCARD.2004.08.003
P478
P577
P698