Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.
about
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Advances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum DisorderDysregulation and restoration of translational homeostasis in fragile X syndromeA critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depressionTherapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and BackDSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesisExpression of the core exon-junction complex factor eukaryotic initiation factor 4A3 is increased during spatial exploration and striatally-mediated learningPhosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formationSelective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication.From FMRP function to potential therapies for fragile X syndrome.FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties.Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinctionThe Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle.mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse eliminationGenomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.Meeting at the crossroads: common mechanisms in Fragile X and Down syndromeDysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and AutismFunctionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience.A transgenic mouse line for collecting ribosome-bound mRNA using the tetracycline transactivator system.Increasing our understanding of human cognition through the study of Fragile X Syndrome.A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging.Triad3A regulates synaptic strength by ubiquitination of Arc.Postsynaptic mGluR5 promotes evoked AMPAR-mediated synaptic transmission onto neocortical layer 2/3 pyramidal neurons during developmentStructural basis of arc binding to synaptic proteins: implications for cognitive disease.Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation micePostsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity.Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depressionFMRP regulates actin filament organization via the armadillo protein p0071.Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models.Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.Activity-dependent neuronal signalling and autism spectrum disorder.Fragile X mental retardation protein and synaptic plasticityNew innovations: therapeutic opportunities for intellectual disabilities.Synaptic adaptations by alcohol and drugs of abuse: changes in microRNA expression and mRNA regulation.
P2860
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P2860
Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Evidence for a fragile X menta ...... tion and long-term depression.
@ast
Evidence for a fragile X menta ...... tion and long-term depression.
@en
type
label
Evidence for a fragile X menta ...... tion and long-term depression.
@ast
Evidence for a fragile X menta ...... tion and long-term depression.
@en
prefLabel
Evidence for a fragile X menta ...... tion and long-term depression.
@ast
Evidence for a fragile X menta ...... tion and long-term depression.
@en
P2860
P1476
Evidence for a fragile X menta ...... ation and long-term depression
@en
P2093
Farr Niere
Kimberly M Huber
P2860
P304
P356
10.1523/JNEUROSCI.4650-11.2012
P407
P577
2012-04-01T00:00:00Z