Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
about
Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons.Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potentialInvestigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons.Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors.Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays.Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones.
P2860
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P2860
Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Synthesis and biological evalu ...... isomerase I (Top1) inhibitors.
@ast
Synthesis and biological evalu ...... isomerase I (Top1) inhibitors.
@en
type
label
Synthesis and biological evalu ...... isomerase I (Top1) inhibitors.
@ast
Synthesis and biological evalu ...... isomerase I (Top1) inhibitors.
@en
prefLabel
Synthesis and biological evalu ...... isomerase I (Top1) inhibitors.
@ast
Synthesis and biological evalu ...... isomerase I (Top1) inhibitors.
@en
P2093
P2860
P356
P1476
Synthesis and biological evalu ...... isomerase I (Top1) inhibitors.
@en
P2093
Adel Chergui
Alena Naumova
Alun Bermingham
Andrew G Stephen
Andrew Morrell
Barry R O'Keefe
Christophe Marchand
Keli Agama
Mark Cushman
Martin Conda-Sheridan
P2860
P304
P356
10.1021/JM300335N
P407
P50
P577
2012-04-26T00:00:00Z