The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled
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Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signalingdifferent Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coliTankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin PunctaWNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation.Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex.The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerizationRegulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destructionReversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex.Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin DegradationThe Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine.New insights into the regulation of Axin function in canonical Wnt signaling pathway.The way Wnt works: components and mechanism.Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.Targeting Tankyrase to Fight WNT-dependent Tumours.Celebrating 30 years of Wnt signaling.Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.Open Biology's first few months.Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo.
P2860
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P248
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P2860
The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The Adenomatous polyposis coli ...... s interaction with Dishevelled
@ast
The Adenomatous polyposis coli ...... s interaction with Dishevelled
@en
type
label
The Adenomatous polyposis coli ...... s interaction with Dishevelled
@ast
The Adenomatous polyposis coli ...... s interaction with Dishevelled
@en
prefLabel
The Adenomatous polyposis coli ...... s interaction with Dishevelled
@ast
The Adenomatous polyposis coli ...... s interaction with Dishevelled
@en
P2093
P2860
P356
P1433
P1476
The Adenomatous polyposis coli ...... s interaction with Dishevelled
@en
P2093
Carolina Mendoza-Topaz
Juliusz Mieszczanek
Mariann Bienz
P2860
P304
P356
10.1098/RSOB.110013
P577
2011-11-01T00:00:00Z