Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.
about
Flavin-Dependent Thymidylate Synthase as a New Antibiotic TargetStrategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosisFolate binding site of flavin-dependent thymidylate synthaseMechanistic and structural basis for inhibition of thymidylate synthase ThyXMycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistanceWhole genome sequencing reveals complex evolution patterns of multidrug-resistant Mycobacterium tuberculosis Beijing strains in patientsThe dUTPase enzyme is essential in Mycobacterium smegmatisDiscovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue.Substrate activation in flavin-dependent thymidylate synthase.Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012Importance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistancePredictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosisCharacterisation of the Mycobacterium tuberculosis alternative sigma factor SigG: its operon and regulonPara-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from MyanmarBinding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis.An unprecedented mechanism of nucleotide methylation in organisms containing thyX.Deletion of sigB Causes Increased Sensitivity to para-Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis.Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex.DNA Replication in Mycobacterium tuberculosis.Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.Genome sequencing reveals novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis.Added value of whole-genome sequencing for management of highly drug-resistant TB.dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains.Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance.Unique Features and Anti-microbial Targeting of Folate- and Flavin-Dependent Methyltransferases Required for Accurate Maintenance of Genetic Information.Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance
P2860
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P2860
Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mycobacterium tuberculosis thy ...... ance to p-aminosalicylic acid.
@ast
Mycobacterium tuberculosis thy ...... ance to p-aminosalicylic acid.
@en
type
label
Mycobacterium tuberculosis thy ...... ance to p-aminosalicylic acid.
@ast
Mycobacterium tuberculosis thy ...... ance to p-aminosalicylic acid.
@en
prefLabel
Mycobacterium tuberculosis thy ...... ance to p-aminosalicylic acid.
@ast
Mycobacterium tuberculosis thy ...... ance to p-aminosalicylic acid.
@en
P2093
P2860
P356
P1433
P1476
Mycobacterium tuberculosis thy ...... ance to p-aminosalicylic acid.
@en
P2093
Amanda S Fivian-Hughes
Elaine O Davis
Joanna Houghton
P2860
P304
P356
10.1099/MIC.0.053983-0
P577
2011-10-27T00:00:00Z