Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.
about
Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasisAlzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells.Mitotic spindle defects and chromosome mis-segregation induced by LDL/cholesterol-implications for Niemann-Pick C1, Alzheimer's disease, and atherosclerosis.Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases.Down syndrome and Alzheimer's disease: Common pathways, common goals.The genomically mosaic brain: aneuploidy and more in neural diversity and disease.Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss.X chromosome aneuploidy in the Alzheimer's disease brain.Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease.Aβ 1-40 enhances the proliferation of human diploid fibroblasts.Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells.A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds β-amyloid (Aβ1-42 ) oligomers.Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death.Functions of kinesin superfamily proteins in neuroreceptor trafficking.Kinesin light chain-1 variant E disrupts axonal transport and Aβ generation in Alzheimer's disease (comment on DOI 10.1002/bies.201400131)Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.Apolipoprotein e: essential catalyst of the Alzheimer amyloid cascade.Brain-derived neurotrophic factor prevents beta- amyloid-induced apoptosis of pheochromocytoma cells by regulating Bax/Bcl-2 expression.Mitotic Defects Lead to Neuronal Aneuploidy and Apoptosis in Frontotemporal Lobar Degeneration Caused by MAPT Mutations.The DNA replication stress hypothesis of Alzheimer's disease.Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease.An integrated bioinformatical analysis to evaluate the role of KIF4A as a prognostic biomarker for breast cancer
P2860
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P2860
Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Alzheimer Aβ disrupts the mito ...... ts mitotic microtubule motors.
@ast
Alzheimer Aβ disrupts the mito ...... ts mitotic microtubule motors.
@en
type
label
Alzheimer Aβ disrupts the mito ...... ts mitotic microtubule motors.
@ast
Alzheimer Aβ disrupts the mito ...... ts mitotic microtubule motors.
@en
prefLabel
Alzheimer Aβ disrupts the mito ...... ts mitotic microtubule motors.
@ast
Alzheimer Aβ disrupts the mito ...... ts mitotic microtubule motors.
@en
P2093
P2860
P356
P1433
P1476
Alzheimer Aβ disrupts the mito ...... ts mitotic microtubule motors.
@en
P2093
Antoneta Granic
Claire E Walczak
Huntington Potter
Jaya Padmanabhan
Sergiy I Borysov
P2860
P304
P356
10.4161/CC.10.9.15478
P577
2011-05-01T00:00:00Z