Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences.
about
Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1.An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract.Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavage.Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway.hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.
P2860
Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences.
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
Rate-determining Step of Flap ...... rinucleotide Repeat Sequences.
@ast
Rate-determining Step of Flap ...... rinucleotide Repeat Sequences.
@en
type
label
Rate-determining Step of Flap ...... rinucleotide Repeat Sequences.
@ast
Rate-determining Step of Flap ...... rinucleotide Repeat Sequences.
@en
prefLabel
Rate-determining Step of Flap ...... rinucleotide Repeat Sequences.
@ast
Rate-determining Step of Flap ...... rinucleotide Repeat Sequences.
@en
P2093
P2860
P356
P1476
Rate-determining Step of Flap ...... rinucleotide Repeat Sequences.
@en
P2093
Katharina Bilotti
Mary E Tarantino
Sarah Delaney
P2860
P304
21154-21162
P356
10.1074/JBC.M115.666438
P407
P577
2015-07-09T00:00:00Z