Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.
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Alzheimer mechanisms and therapeutic strategiesAutophagy-Related Deubiquitinating Enzymes Involved in Health and DiseaseAutophagy modulation as a potential therapeutic target for diverse diseasesSingle-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's diseaseLysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular ToxicityAftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations.Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's diseaseLongitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic micePathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Epigallocatechin-3-gallate attenuates impairment of learning and memory in chronic unpredictable mild stress-treated rats by restoring hippocampal autophagic fluxAutophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studiesImpaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons.Plasma Cystatin C and High-Density Lipoprotein Are Important Biomarkers of Alzheimer's Disease and Vascular Dementia: A Cross-Sectional Study.Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?Transcriptional and post-transcriptional regulation of β-secretase.Aging and the aggregating proteome.Integrating pathways of Parkinson's disease in a molecular interaction map.Dysfunctional autophagy in Alzheimer's disease: pathogenic roles and therapeutic implicationsAutophagy-ERK1/2-Involved Disinhibition of Hippocampal Neurons Contributes to the Pre-Synaptic Toxicity Induced by Aβ42 Exposure.Methodological approaches and insights on protein aggregation in biological systems.Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine.Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease.Modulation of Autophagy as a Therapeutic Target for Alzheimer's Disease.Mouse models of Down syndrome: gene content and consequences.Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation.Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration.Overexpression of let-7a increases neurotoxicity in a PC12 cell model of Alzheimer's disease via regulating autophagy.GSK-3 and lysosomes meet in Alzheimer's disease.Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease.RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.Acute spinal cord injury could cause activation of autophagy in dorsal root ganglia.The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability.The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson's Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy.Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice.
P2860
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P2860
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Therapeutic effects of remedia ...... hancing lysosomal proteolysis.
@ast
Therapeutic effects of remedia ...... hancing lysosomal proteolysis.
@en
type
label
Therapeutic effects of remedia ...... hancing lysosomal proteolysis.
@ast
Therapeutic effects of remedia ...... hancing lysosomal proteolysis.
@en
prefLabel
Therapeutic effects of remedia ...... hancing lysosomal proteolysis.
@ast
Therapeutic effects of remedia ...... hancing lysosomal proteolysis.
@en
P2093
P50
P921
P356
P1433
P1476
Therapeutic effects of remedia ...... nhancing lysosomal proteolysis
@en
P2093
Asok Kumar
Austin J Yang
Corrinne M Peterhoff
Daniel W Wesson
David Westaway
Dun-Sheng Yang
Efrat Levy
Masuo Ohno
Monika Pawlik
Panaiyur S Mohan
P304
P356
10.4161/AUTO.7.7.15596
P577
2011-07-01T00:00:00Z