5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. - Wikidata - wikimedia - TriplyDB

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

http://www.wikidata.org/entity/Q35987054

about

Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain The search for novel analgesics: targets and mechanisms TRPA1 as a drug target--promise and challenges Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model TRPA1 mediates mechanical sensitization in nociceptors during inflammation Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity.Are sensory TRP channels biological alarms for lipid peroxidation?TRPA1: a transducer and amplifier of pain and inflammation.Targeting TRP channels for novel migraine therapeutics.Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.Modulation of K(Ca)3.1 channels by eicosanoids, omega-3 fatty acids, and molecular determinants Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex.Nociceptor Sensitization Depends on Age and Pain Chronicity(1,2,3).4α-phorbol 12,13-didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4 Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons.The fundamental unit of pain is the cell.Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels.The role of the central nervous system in osteoarthritis pain and implications for rehabilitation.The transient receptor potential channel TRPA1: from gene to pathophysiology.Endothelial control of vasodilation: integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids.Inhibitors of the arachidonic acid cascade: interfering with multiple pathways.Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics.TRP Channels Involved in Spontaneous L-Glutamate Release Enhancement in the Adult Rat Spinal Substantia Gelatinosa.Sensory TRP channels: the key transducers of nociception and pain.Released lipids regulate transient receptor potential channel (TRP)-dependent oral cancer pain.The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.Breaking barriers to novel analgesic drug development.TRPs in Pain Sensation TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis.Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury.Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1.14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity.Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice.CYP2J2 - regulation, function and polymorphism.Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation.

P2860

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P2860

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

http://www.wikidata.org/entity/Q35987054

description

2012 nî lūn-bûn

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2012年论文

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2012年论文

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2012年论文

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name

5,6-EET is released upon neuro ...... on central afferent terminals.

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5,6-EET is released upon neuro ...... on central afferent terminals.

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5,6-EET is released upon neuro ...... on central afferent terminals.

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5,6-EET is released upon neuro ...... on central afferent terminals.

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5,6-EET is released upon neuro ...... on central afferent terminals.

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JNEUROSCI.5793-11.2012

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Journal of Neuroscience

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5,6-EET is released upon neuro ...... on central afferent terminals.

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P2093

Achim Schmidtko

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Carlo Angioni

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Christian Brenneis

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Christian von Hehn

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Chul-Kyu Park

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Clifford J Woolf

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Dong Dong Zhang

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Enrique J Cobos

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Gerd Geisslinger

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Klaus Scholich

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P2860

Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents

TRPA1 mediates formalin-induced pain

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

TRPA1 contributes to cold hypersensitivity

TRPA1 is a major oxidant sensor in murine airway sensory neurons

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

TRP channels as cellular sensors

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10.1523/JNEUROSCI.5793-11.2012

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18

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32

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Marco Sisignano

Nader Ghasemlou

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2012-05-01T00:00:00Z

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22553041

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3359875

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