Modulation of neurodegeneration by molecular chaperones.
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Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugsJ protein mutations and resulting proteostasis collapsePharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant ProteinsQuantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosisCharacterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosisThe ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by HipIn vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic studyStress-induced localization of HSPA6 (HSP70B') and HSPA1A (HSP70-1) proteins to centrioles in human neuronal cellsCystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.Altered ribostasis: RNA-protein granules in degenerative disordersThe Brichos domain of prosurfactant protein C can hold and fold a transmembrane segmentMisfolded proteins partition between two distinct quality control compartmentsThe cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome systemHeat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseasesMolecular chaperones and co-chaperones in Parkinson diseaseTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesHeat shock proteins at the crossroads between cancer and Alzheimer's diseasePositive or negative involvement of heat shock proteins in multiple sclerosis pathogenesis: an overviewLysosomal storage diseases and the heat shock response: convergences and therapeutic opportunitiesTherapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseHuntington's disease: underlying molecular mechanisms and emerging conceptsAn intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregationAn ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanismCrystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens functionThe Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins.Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathyThe cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutantsAggresome formation and neurodegenerative diseases: therapeutic implicationsThe neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteinsThe gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperoneCo-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapyER chaperones in mammalian development and human diseasesProgress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promiseProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusRiluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotectionIn vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoformsMethamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatumCell line specific modulation of extracellular aβ42 by Hsp40
P2860
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P2860
Modulation of neurodegeneration by molecular chaperones.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Modulation of neurodegeneration by molecular chaperones.
@ast
Modulation of neurodegeneration by molecular chaperones.
@en
type
label
Modulation of neurodegeneration by molecular chaperones.
@ast
Modulation of neurodegeneration by molecular chaperones.
@en
prefLabel
Modulation of neurodegeneration by molecular chaperones.
@ast
Modulation of neurodegeneration by molecular chaperones.
@en
P356
P1476
Modulation of neurodegeneration by molecular chaperones.
@en
P2093
Jennifer L Wacker
Paul J Muchowski
P2888
P356
10.1038/NRN1587
P407
P577
2005-01-01T00:00:00Z