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Mastocytosis: pathology, genetics, and current options for therapy.

Mastocytosis: pathology, genetics, and current options for therapy.

http://www.wikidata.org/entity/Q35994902

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Case-control cohort study of patients' perceptions of disability in mastocytosis Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells MicroRNA-221-222 regulate the cell cycle in mast cells KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report.Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcome Systemic mastocytosis: a rare case of increased liver stiffness.Eosinophilia in mast cell disease Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma cell myeloma.A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients Recent advances in the understanding of mastocytosis: the role of KIT mutations.KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation Gastrointestinal manifestations of systemic mastocytosis Overexpression of miR-9 in mast cells is associated with invasive behavior and spontaneous metastasis.Osteoporosis and osteopathy markers in patients with mastocytosis.Allele-specific polymerase chain reaction for the imatinib-resistant KIT D816V and D816F mutations in mastocytosis and acute myelogenous leukemia.Clonality and molecular pathogenesis of mastocytosis.Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder Chronic myeloproliferative disorders: a tyrosine kinase tale.Characterization of various types of mast cells derived from model mice of familial gastrointestinal stromal tumors with KIT-Asp818Tyr mutation.Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation.Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors.A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation Mast cell transcriptional networks.Mast cells and mastocytosis.Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy.Generation and characterization of novel canine malignant mast cell line CL1.Cutaneous mastocytosis: a review focusing on the pediatric population.Bone marrow mast cell burden and serum tryptase level as markers of response in patients with systemic mastocytosis.Adult mastocytosis: a review of the Santo António Hospital 's experience and an evaluation of World Health Organization criteria for the diagnosis of systemic disease.Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives.Advances and controversies in the diagnosis, pathogenesis, and treatment of systemic mastocytosis.Diagnosis, progression patterns and prognostication in mastocytosis.Mast cells, disease and gastrointestinal cancer: A comprehensive review of recent findings Therapeutic targeting of c-KIT in cancer.Anesthetic considerations in pediatric mastocytosis: a review.Detection of phospho-STAT5 in mast cells: a reliable phenotypic marker of systemic mast cell disease that reflects constitutive tyrosine kinase activation.Mastocytosis: the puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease.BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils.

P2860

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P2860

Mastocytosis: pathology, genetics, and current options for therapy.

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Mastocytosis: pathology, genetics, and current options for therapy.

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Mastocytosis: pathology, genetics, and current options for therapy.

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Mastocytosis: pathology, genetics, and current options for therapy.

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Leukemia & Lymphoma

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Mastocytosis: pathology, genetics, and current options for therapy.

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Cem Akin

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Dean D Metcalfe

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Hans-Peter Horny

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Karl Sotlar

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Luis Escribano

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Manuela Födinger

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Matthias Mayerhofer

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P2860

Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis

One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes

CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy

Treatment of cutaneous mastocytosis

Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy.

A case of 'smouldering' mastocytosis with high mast cell burden, monoclonal myeloid cells, and C-KIT mutation Asp-816-Val.

Mastocytosis: mediator-related signs and symptoms.

Hematologic manifestations of systemic mast cell disease: a prospective study of laboratory and morphologic features and their relation to prognosis.

Blood findings in generalized mastocytosis: evidence of frequent simultaneous occurrence of myeloproliferative disorders.

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