Cells resistant to interferon are defective in activation of a promoter-binding factor.
about
Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysisISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chainsThe induction of type I interferon production in hepatitis C-infected patients.STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activitiesEnhancement of sensitivity of human lung adenocarcinoma cells to growth-inhibitory activity of interferon alpha by differentiation-inducing agentsInterferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcriptInterferon-alpha induces the expression of the L-selectin homing receptor in human B lymphoid cells.Protein binding to the interferon response enhancer correlates with interferon induction of 2'-5'-oligoadenylate synthetase in normal and interferon-resistant Friend cellsBALB/c-3T3 fibroblasts resistant to growth inhibition by beta interferon exhibit aberrant platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor signal transduction.Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cellsTyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection.In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element.Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathwaysAn Epstein-Barr virus immortalization associated gene segment interferes specifically with the IFN-induced anti-proliferative response in human B-lymphoid cell lines.Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3The EBNA2-related resistance towards alpha interferon (IFN-alpha) in Burkitt's lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3.
P2860
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P2860
Cells resistant to interferon are defective in activation of a promoter-binding factor.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Cells resistant to interferon are defective in activation of a promoter-binding factor.
@ast
Cells resistant to interferon are defective in activation of a promoter-binding factor.
@en
type
label
Cells resistant to interferon are defective in activation of a promoter-binding factor.
@ast
Cells resistant to interferon are defective in activation of a promoter-binding factor.
@en
prefLabel
Cells resistant to interferon are defective in activation of a promoter-binding factor.
@ast
Cells resistant to interferon are defective in activation of a promoter-binding factor.
@en
P2093
P2860
P1433
P1476
Cells resistant to interferon are defective in activation of a promoter-binding factor
@en
P2093
Darnell JE Jr
Kessler DS
Pfeffer LM
P2860
P304
P356
10.1002/J.1460-2075.1988.TB03262.X
P407
P50
P577
1988-12-01T00:00:00Z