The search of DNA-intercalators as antitumoral drugs: what it worked and what did not work.
about
Dihydroimidazophenanthridinium (DIP)-based DNA binding agents with tuneable structures and biological activity.New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents.Characterization of aziridinylbenzoquinone DNA cross-links by liquid chromatography-infrared multiphoton dissociation-mass spectrometry.Interactions of sulfur-containing acridine ligands with DNA by ESI-MS.4-Methyl-1-phenyl-quinolin-2(1H)-onePolymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer.Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity.Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicityInduction of immunogenic cell death of tumors by newly synthesized heterocyclic quinone derivative.Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replicationAn omics perspective to the molecular mechanisms of anticancer metallo-drugs in the computational microscope era.A targeted DNA substrate mechanism for the inhibition of HIV-1 integrase by inhibitors with antiretroviral activity.Synthesis and Cytotoxicity Study of New Cyclopenta [b] quinoline-1,8-dione Derivatives.DNA binding, photocleavage, and topoisomerase inhibition of functionalized ruthenium(II)-polypyridine complexes.Modeling and Analysis of Intercalant Effects on Circular DNA ConformationNovel and emerging approaches for the delivery of metallo-drugs.Acridine and acridinones: old and new structures with antimalarial activity.Electrolytes in biomolecular systems studied with the 3D-RISM/RISM theory.RNA targeting by small molecules: Binding of protoberberine, benzophenanthridine and aristolochia alkaloids to various RNA structures.Metal complex interactions with DNA.DNA Interaction Studies of Selected Polyamine Conjugates.Cell Cycle Arrest and Induction of Apoptosis in Colon Adenocarcinoma Cells by a DNA Intercalative Quinoline Derivative, 4-Morpholinopyrimido [4',5':4,5] Selenolo (2,3-b) Quinoline.Pyrido[1,2-a]pyrimidinium ions--a novel bridgehead nitrogen heterocycles: synthesis, characterisation, and elucidation of DNA binding and cell imaging properties.DNA intercalative 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells.The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents.Synthesis of β-carboline-benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation.TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells.1,8-Naphthalimide: A Potent DNA Intercalator and Target for Cancer Therapy.A novel DNA intercalator, 8-methoxy pyrimido[4',5':4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor.A mechanistic approach for the DNA binding of chiral enantiomeric L- and D-tryptophan-derived metal complexes of 1,2-DACH: cleavage and antitumor activity.A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells.Synthesis and analysis of potential DNA intercalators containing quinoline-glucose hybrids.Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.Biological properties of 4-methyl-2,7-diamino-5,10-diphenyl-4,9-diazapyrenium hydrogensulfate (ADAP).Novel N-(3-carboxyl-9-benzyl-carboline-1-yl)ethylamino acids: synthesis, anti-proliferation activity and two-step-course of intercalation with calf thymus DNA.Targeting topoisomerase II with the chiral DNA-intercalating ruthenium(II) polypyridyl complexes.Dinuclear ruthenium(II) triple-stranded helicates: luminescent supramolecular cylinders that bind and coil DNA and exhibit activity against cancer cell lines.Systematical investigation of binding interaction between novel ruthenium(II) arene complex with curcumin analogs and ctDNA.
P2860
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P2860
The search of DNA-intercalators as antitumoral drugs: what it worked and what did not work.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The search of DNA-intercalator ...... worked and what did not work.
@ast
The search of DNA-intercalator ...... worked and what did not work.
@en
type
label
The search of DNA-intercalator ...... worked and what did not work.
@ast
The search of DNA-intercalator ...... worked and what did not work.
@en
prefLabel
The search of DNA-intercalator ...... worked and what did not work.
@ast
The search of DNA-intercalator ...... worked and what did not work.
@en
P356
P1476
The search of DNA-intercalator ...... t worked and what did not work
@en
P2093
L Chacón-García
P304
P356
10.2174/0929867053363414
P577
2005-01-01T00:00:00Z