Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency.
about
Cyclic nucleotide-gated channel α-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransductionEndoplasmic reticulum stress and the unfolded protein responses in retinal degeneration.Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration.An active component of Achyranthes bidentata polypeptides provides neuroprotection through inhibition of mitochondrial-dependent apoptotic pathway in cultured neurons and in animal models of cerebral ischemiaVitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsiaTargeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration.Mutation of ATF6 causes autosomal recessive achromatopsia.cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.Correlation of ER stress and retinal degeneration in tubby mice.Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural FlexibilityTransient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia.Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells.Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study.cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.Two pathways of rod photoreceptor cell death induced by elevated cGMP.Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2.Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa.Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches.Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration.Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.
P2860
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P2860
Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Endoplasmic reticulum stress-a ...... tide-gated channel deficiency.
@ast
Endoplasmic reticulum stress-a ...... tide-gated channel deficiency.
@en
type
label
Endoplasmic reticulum stress-a ...... tide-gated channel deficiency.
@ast
Endoplasmic reticulum stress-a ...... tide-gated channel deficiency.
@en
prefLabel
Endoplasmic reticulum stress-a ...... tide-gated channel deficiency.
@ast
Endoplasmic reticulum stress-a ...... tide-gated channel deficiency.
@en
P2093
P2860
P356
P1476
Endoplasmic reticulum stress-a ...... tide-gated channel deficiency.
@en
P2093
Arjun Thapa
Hongwei Ma
Jianhua Xu
Lynsie Morris
Martin Biel
Stylianos Michalakis
Xi-Qin Ding
P2860
P304
18018-18029
P356
10.1074/JBC.M112.342220
P407
P577
2012-04-09T00:00:00Z