Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy
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pH sensing and regulation in cancerNuclear localization of the mitochondrial factor HIGD1A during metabolic stressOvercoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune DysfunctionMetabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentialityTargeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitorsCarbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors.Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions.COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatmentCombination therapy in combating cancer.Microenvironmental induced essentiality of autophagyBevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomasTranscription factor Ets1 cooperates with estrogen receptor α to stimulate estradiol-dependent growth in breast cancer cells and tumors.The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesionsContrasting effects of sunitinib within in vivo models of metastasis.Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models.Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast CancerCombination of lactate calcium salt with 5-indanesulfonamide and α-cyano-4-hydroxycinnamic acid to enhance the antitumor effect on HCT116 cells via intracellular acidificationMetformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma.Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.Changes in tumour vessel density upon treatment with anti-angiogenic agents: relationship with response and resistance to therapy.Radiogenomics Monitoring in Breast Cancer Identifies Metabolism and Immune Checkpoints as Early Actionable Mechanisms of Resistance to Anti-angiogenic Treatment.The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.Anti-angiogenic Therapy in Cancer: Downsides and New Pivots for Precision Medicine.Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies.Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells.COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs.Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors.The chemistry, physiology and pathology of pH in cancer.Current evidence of temozolomide and bevacizumab in treatment of gliomas.Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.Predictive tissue biomarkers for bevacizumab-containing therapy in metastatic colorectal cancer: an update.Recent advance in molecular angiogenesis in glioblastoma: the challenge and hope for anti-angiogenic therapy.Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1α and NF-κB-dependent mechanisms.Hypoxia and cellular metabolism in tumour pathophysiology.CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis.Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma.Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivoMethods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia.
P2860
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P2860
Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Carbonic anhydrase IX promotes ...... ion enhances anti-VEGF therapy
@ast
Carbonic anhydrase IX promotes ...... ion enhances anti-VEGF therapy
@en
type
label
Carbonic anhydrase IX promotes ...... ion enhances anti-VEGF therapy
@ast
Carbonic anhydrase IX promotes ...... ion enhances anti-VEGF therapy
@en
prefLabel
Carbonic anhydrase IX promotes ...... ion enhances anti-VEGF therapy
@ast
Carbonic anhydrase IX promotes ...... ion enhances anti-VEGF therapy
@en
P2093
P2860
P1476
Carbonic anhydrase IX promotes ...... ion enhances anti-VEGF therapy
@en
P2093
Alan McIntyre
Helen Turley
Ioanna Ledaki
Ji-Liang Li
Kevin Gatter
Pawel Swietach
Richard D Vaughan-Jones
Russell Leek
Shalini Patiar
Simon Wigfield
P2860
P304
P356
10.1158/1078-0432.CCR-11-1877
P407
P577
2012-04-12T00:00:00Z