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Altered inflammatory responses in leukotriene-deficient mice

Altered inflammatory responses in leukotriene-deficient mice

http://www.wikidata.org/entity/Q36008360

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A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders The role of lipoxygenases in pathophysiology; new insights and future perspectives Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1 Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.Identification of ALOX5 as a gene regulating adiposity and pancreatic function.Allergic lung responses are increased in prostaglandin H synthase-deficient mice.Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo An in vivo approach showing the chemotactic activity of leukotriene B(4) in acute renal ischemic-reperfusion injury.2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.ONZIN deficiency attenuates contact hypersensitivity responses in mice Neutrophil-derived leukotriene B4 is required for inflammatory arthritis Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors.Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity.Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis 5-Lipoxygenase facilitates healing after myocardial infarction Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg mice Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation.Evaluation of Artemisia amygdalina D. for Anti-Inflammatory and Immunomodulatory Potential.Endocannabinoid-mediated control of synaptic transmission.Role of TNFR-related 2 mediated immune responses in dextran sulfate sodium-induced inflammatory bowel disease.Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer.The complement system in ischemia-reperfusion injuries Cytochrome P450 and Lipoxygenase Metabolites on Renal Function.Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats.Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells.Impact of knockout mice in toxicology.Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP).Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase.Protection from pulmonary fibrosis in leukotriene-deficient mice.

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P2860

Altered inflammatory responses in leukotriene-deficient mice

http://www.wikidata.org/entity/Q36008360

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1994 nî lūn-bûn

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1994年論文

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1994年论文

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1994年论文

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name

Altered inflammatory responses in leukotriene-deficient mice

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Altered inflammatory responses in leukotriene-deficient mice

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Altered inflammatory responses in leukotriene-deficient mice

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Altered inflammatory responses in leukotriene-deficient mice

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Altered inflammatory responses in leukotriene-deficient mice

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Altered inflammatory responses in leukotriene-deficient mice

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Altered inflammatory responses in leukotriene-deficient mice

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A M Latour

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B H Koller

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J L Goulet

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J N Snouwaert

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T M Coffman

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P2860

Characterization of the human 5-lipoxygenase gene

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response

Cloning of the cDNA for human 5-lipoxygenase

Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.

Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils.

Glucocorticoid protection against PAF-acether toxicity in mice.

Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.

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Arachidonate 5-lipoxygenase

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