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Targeting sphingosine-1-phosphate in hematologic malignancies

Targeting sphingosine-1-phosphate in hematologic malignancies

http://www.wikidata.org/entity/Q36011176

about

Acid ceramidase is upregulated in AML and represents a novel therapeutic target.Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.Development of small-molecule inhibitors of sphingosine-1-phosphate signaling Novel selective allosteric and bitopic ligands for the S1P(3) receptor.Influenza viral manipulation of sphingolipid metabolism and signaling to modulate host defense system.Sphingolipids and mitochondrial apoptosis.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Targeting sphingosine-1-phosphate signaling for cancer therapy.SphK2 over-expression promotes osteosarcoma cell growth.Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells.

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Targeting sphingosine-1-phosphate in hematologic malignancies

http://www.wikidata.org/entity/Q36011176

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Targeting sphingosine-1-phosphate in hematologic malignancies

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Targeting sphingosine-1-phosphate in hematologic malignancies

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type

label

Targeting sphingosine-1-phosphate in hematologic malignancies

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Targeting sphingosine-1-phosphate in hematologic malignancies

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prefLabel

Targeting sphingosine-1-phosphate in hematologic malignancies

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Targeting sphingosine-1-phosphate in hematologic malignancies

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Anti-Cancer Agents in Medicinal Chemistry

P1476

Targeting sphingosine-1-phosphate in hematologic malignancies

@en

P2093

Christina E Stevenson

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Kazuaki Takabe

http://www.w3.org/2001/XMLSchema#string

Masayuki Nagahashi

http://www.w3.org/2001/XMLSchema#string

Sheldon Milstien

http://www.w3.org/2001/XMLSchema#string

P2860

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors

Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers

Sphingosine 1-phosphate and cancer.

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

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