The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathwaysValproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway.Evasion of early antiviral responses by herpes simplex viruses.H11/HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell Life/Death Decisions and Human DiseaseIn vitro maintenance of Clonorchis sinensis adult wormsVaricella-zoster virus ORF12 protein activates the phosphatidylinositol 3-kinase/Akt pathway to regulate cell cycle progression.The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation.Multi-targeted neuroprotection by the HSV-2 gene ICP10PK includes robust bystander activity through PI3-K/Akt and/or MEK/ERK-dependent neuronal release of vascular endothelial growth factor and fractalkine.Calpain-dependent clearance of the autophagy protein p62/SQSTM1 is a contributor to ΔPK oncolytic activity in melanoma.The protective effects of insulin and natural honey against hippocampal cell death in streptozotocin-induced diabetic rats.The oncolytic virus ΔPK has multimodal anti-tumor activity.The HSV-2 mutant DeltaPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins.DeltaRR vaccination protects from KA-induced seizures and neuronal loss through ICP10PK-mediated modulation of the neuronal-microglial axis.ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+.Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats.
P2860
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P2860
The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
@zh-hant
name
The HSV-2 protein ICP10PK prev ...... with glutamate excitotoxicity.
@ast
The HSV-2 protein ICP10PK prev ...... with glutamate excitotoxicity.
@en
type
label
The HSV-2 protein ICP10PK prev ...... with glutamate excitotoxicity.
@ast
The HSV-2 protein ICP10PK prev ...... with glutamate excitotoxicity.
@en
prefLabel
The HSV-2 protein ICP10PK prev ...... with glutamate excitotoxicity.
@ast
The HSV-2 protein ICP10PK prev ...... with glutamate excitotoxicity.
@en
P2093
P2860
P1476
The HSV-2 protein ICP10PK prev ...... with glutamate excitotoxicity
@en
P2093
Erin K Golembewski
Laure Aurelian
Samantha Q Wales
P2860
P304
P356
10.1016/J.EXPNEUROL.2006.08.022
P407
P577
2006-10-16T00:00:00Z