Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C
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Pancreatic cancer risk in hereditary pancreatitisLong-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme ActivationGenetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.Advances in acute and chronic pancreatitis: from development to inflammation and repair.Risk factors for pancreatic cancer: underlying mechanisms and potential targets.Familial pancreatic cancer: genetic advances.Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis.Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis.Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitisFunctional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease.Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.The role of protein synthesis and digestive enzymes in acinar cell injury.Pancreatitis in dogs and cats: definitions and pathophysiology.Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.Pancreatic Cancer Screening.Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis.
P2860
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P2860
Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C
description
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name
Increased activation of heredi ...... in presence of chymotrypsin C
@ast
Increased activation of heredi ...... in presence of chymotrypsin C
@en
type
label
Increased activation of heredi ...... in presence of chymotrypsin C
@ast
Increased activation of heredi ...... in presence of chymotrypsin C
@en
prefLabel
Increased activation of heredi ...... in presence of chymotrypsin C
@ast
Increased activation of heredi ...... in presence of chymotrypsin C
@en
P2860
P356
P1476
Increased activation of heredi ...... in presence of chymotrypsin C
@en
P2093
András Szabó
Miklós Sahin-Tóth
P2860
P304
20701-20710
P356
10.1074/JBC.M112.360065
P407
P577
2012-04-26T00:00:00Z