Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice - Wikidata - wikimedia - TriplyDB

Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice

Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice

http://www.wikidata.org/entity/Q36018138

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HUMAN MICROBIOTA. Small molecules from the human microbiota Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis Complete genome sequence analysis of Nocardia brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.A Duplicated ESAT-6 Region of ESX-5 Is Involved in Protein Export and Virulence of Mycobacteria.A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D.Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling An update on vaccines for tuberculosis - there is more to it than just waning of BCG efficacy with time.Virulence factors of the Mycobacterium tuberculosis complex Recycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.MmpL3 a potential new target for development of novel anti-tuberculosis drugs.Shared characteristics between Mycobacterium tuberculosis and fungi contribute to virulence.Analyses of methyltransferases across the pathogenicity spectrum of different mycobacterial species point to an extremophile connection.RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques.The gene fmt, encoding tRNAfMet-formyl transferase, is essential for normal growth of M. bovis, but not for viability.Mycobacteria-derived biomarkers for tuberculosis diagnosis.Impact of the epoxide hydrolase EphD on the metabolism of mycolic acids in mycobacteria.

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Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice

http://www.wikidata.org/entity/Q36018138

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice

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Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice

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Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice

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Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice

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Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice

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Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice

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Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice

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Daniel Barkan

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Dorsaf Hedhli

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Han-Guang Yan

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Michael S Glickman

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P2860

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice

Mycolic acids: structure, biosynthesis and physiological functions

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production

The effect of oxygenated mycolic acid composition on cell wall function and macrophage growth in Mycobacterium tuberculosis

S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases

Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule

Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis. Structural analysis of fatty acids of a mutant strain deviod of methoxy- and ketomycolates

Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence

The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid

The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase

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1958-1968

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10.1128/IAI.00021-12

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6

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22431648

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Mycobacterium tuberculosis

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3370573

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