Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice
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HUMAN MICROBIOTA. Small molecules from the human microbiotaMycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesisComplete genome sequence analysis of Nocardia brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesisM.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.A Duplicated ESAT-6 Region of ESX-5 Is Involved in Protein Export and Virulence of Mycobacteria.A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazoneCharacterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D.Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profilingAn update on vaccines for tuberculosis - there is more to it than just waning of BCG efficacy with time.Virulence factors of the Mycobacterium tuberculosis complexRecycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.MmpL3 a potential new target for development of novel anti-tuberculosis drugs.Shared characteristics between Mycobacterium tuberculosis and fungi contribute to virulence.Analyses of methyltransferases across the pathogenicity spectrum of different mycobacterial species point to an extremophile connection.RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of MycobacteriaRecombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques.The gene fmt, encoding tRNAfMet-formyl transferase, is essential for normal growth of M. bovis, but not for viability.Mycobacteria-derived biomarkers for tuberculosis diagnosis.Impact of the epoxide hydrolase EphD on the metabolism of mycolic acids in mycobacteria.
P2860
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P2860
Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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name
Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice
@ast
Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice
@en
type
label
Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice
@ast
Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice
@en
prefLabel
Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice
@ast
Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice
@en
P2093
P2860
P356
P1476
Mycobacterium tuberculosis lac ...... and hyperinflammatory in mice
@en
P2093
Daniel Barkan
Dorsaf Hedhli
Han-Guang Yan
Michael S Glickman
P2860
P304
P356
10.1128/IAI.00021-12
P407
P50
P577
2012-03-19T00:00:00Z