Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
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Structural basis for the inhibition ofMycobacterium tuberculosisL,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strainsStructure of LdtMt2, anL,D-transpeptidase fromMycobacterium tuberculosisStructures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosisRepurposing clinically approved cephalosporins for tuberculosis therapyBinding and processing of β-lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis.Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.Non-classical transpeptidases yield insight into new antibacterialsFatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosisSynthetic lethality reveals mechanisms of Mycobacterium tuberculosis resistance to β-lactamsThe cell envelope glycoconjugates of Mycobacterium tuberculosisCombinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis InfectionInactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporinsThe external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growthThe Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis.Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosisl,d-transpeptidase 2In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosisProgress in targeting cell envelope biogenesis in Mycobacterium tuberculosis.Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactamsIs repositioning of drugs a viable alternative in the treatment of tuberculosis?Targeting the mycobacterial envelope for tuberculosis drug development.Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.An Update on Repurposed Medications for the Treatment of Drug-Resistant Tuberculosis.Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.β-Lactamase inhibition by avibactam in Mycobacterium abscessus.The Antituberculosis Drug Ethambutol Selectively Blocks Apical Growth in CMN Group Bacteria.Mutation in an Unannotated Protein Confers Carbapenem Resistance in Mycobacterium tuberculosis.Recognizing drug targets using evolutionary information: implications for repurposing FDA-approved drugs against Mycobacterium tuberculosis H37Rv.Meropenem-clavulanic acid has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis.2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.Determination of compound kill kinetics against Mycobacterium tuberculosis.Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages.Phosphate Promotes the Recovery of Mycobacterium tuberculosis β-Lactamase from Clavulanic Acid Inhibition.Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation.Activity of faropenem with and without rifampicin against Mycobacterium tuberculosis: evaluation in a whole-blood bactericidal activity trial.Solid-state stability and compatibility studies of clavulanate potassium.
P2860
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P2860
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
@ast
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
@en
type
label
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
@ast
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
@en
prefLabel
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
@ast
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
@en
P2093
P2860
P356
P1476
Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.
@en
P2093
Daniel Schimel
Danielle Weiner
Emmanuel Dayao
Helena I M Boshoff
Kathleen England
Kriti Arora
P2860
P304
P356
10.1128/AAC.05690-11
P407
P577
2012-03-26T00:00:00Z