Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo. - Wikidata - wikimedia - TriplyDB

Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

http://www.wikidata.org/entity/Q36018749

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Structural basis for the inhibition ofMycobacterium tuberculosisL,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains Structure of LdtMt2, anL,D-transpeptidase fromMycobacterium tuberculosis Structures of free and inhibited forms of the L,D-transpeptidase LdtMt1 from Mycobacterium tuberculosis Repurposing clinically approved cephalosporins for tuberculosis therapy Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2 from Mycobacterium tuberculosis.Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.Non-classical transpeptidases yield insight into new antibacterials Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis Synthetic lethality reveals mechanisms of Mycobacterium tuberculosis resistance to β-lactams The cell envelope glycoconjugates of Mycobacterium tuberculosis Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis.Toward antituberculosis drugs: in silico screening of synthetic compounds against Mycobacterium tuberculosisl,d-transpeptidase 2 In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis.Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactams Is repositioning of drugs a viable alternative in the treatment of tuberculosis?Targeting the mycobacterial envelope for tuberculosis drug development.Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.An Update on Repurposed Medications for the Treatment of Drug-Resistant Tuberculosis.Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.β-Lactamase inhibition by avibactam in Mycobacterium abscessus.The Antituberculosis Drug Ethambutol Selectively Blocks Apical Growth in CMN Group Bacteria.Mutation in an Unannotated Protein Confers Carbapenem Resistance in Mycobacterium tuberculosis.Recognizing drug targets using evolutionary information: implications for repurposing FDA-approved drugs against Mycobacterium tuberculosis H37Rv.Meropenem-clavulanic acid has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis.2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.Determination of compound kill kinetics against Mycobacterium tuberculosis.Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages.Phosphate Promotes the Recovery of Mycobacterium tuberculosis β-Lactamase from Clavulanic Acid Inhibition.Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation.Activity of faropenem with and without rifampicin against Mycobacterium tuberculosis: evaluation in a whole-blood bactericidal activity trial.Solid-state stability and compatibility studies of clavulanate potassium.

P2860

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P2860

Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

http://www.wikidata.org/entity/Q36018749

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2012 nî lūn-bûn

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2012年论文

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

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Antimicrobial Agents and Chemotherapy

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

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Daniel Schimel

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Danielle Weiner

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Emmanuel Dayao

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Helena I M Boshoff

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Kathleen England

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Kriti Arora

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P2860

Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics

Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates

Comparative stability studies of antipseudomonal beta-lactams for potential administration through portable elastomeric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units)

A review of the antimicrobial activity of clavulanate.

Carbapenems: a potent class of antibiotics.

Meropenem: a review of its use in the treatment of serious bacterial infections.

Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I.

Meropenem. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.

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10.1128/AAC.05690-11

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6

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56

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Clifton E Barry

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2012-03-26T00:00:00Z

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22450968

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Mycobacterium tuberculosis

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