Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.
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Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5Computational medicine: translating models to clinical careBridging scales through multiscale modeling: a case study on protein kinase ACaMKII-dependent regulation of cardiac Na(+) homeostasisNa+ channel function, regulation, structure, trafficking and sequestrationMechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulencePerspective: a dynamics-based classification of ventricular arrhythmiasPost-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmiasModeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiberA compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytesParameterization for In-Silico Modeling of Ion Channel Interactions with DrugsComputational modeling of cardiac fibroblasts and fibrosisCardiac models in drug discovery and development: a review.A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction.Relationship between ST-segment morphology and conduction disturbances detected by signal-averaged electrocardiography in Brugada syndrome.Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation.p.Y1449C SCN5A mutation associated with overlap disorder comprising conduction disease, Brugada syndrome, and atrial flutter.Cardiac Na Channels: Structure to FunctionSodium channel carboxyl-terminal residue regulates fast inactivation.Inherited disorders of voltage-gated sodium channels.A quantitative model of human jejunal smooth muscle cell electrophysiology.Mathematical model of the neonatal mouse ventricular action potential.Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndromeCellular cardiac electrophysiology modeling with Chaste and CellML.Defective cardiac ion channels: from mutations to clinical syndromes.Drug-induced torsades de pointes and implications for drug development.Cardiac sodium channel diseases.Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channelsCalcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytesA sodium channel pore mutation causing Brugada syndromeKinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patientsAltered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes.Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation.Computational physiology and the Physiome Project.Modelling and imaging cardiac repolarization abnormalities.Computational biology in the study of cardiac ion channels and cell electrophysiology.Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.Molecular biology of channelopathies: impact on diagnosis and treatment.
P2860
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P2860
Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Na(+) channel mutation that ca ...... simulation study of mechanism.
@ast
Na(+) channel mutation that ca ...... simulation study of mechanism.
@en
type
label
Na(+) channel mutation that ca ...... simulation study of mechanism.
@ast
Na(+) channel mutation that ca ...... simulation study of mechanism.
@en
prefLabel
Na(+) channel mutation that ca ...... simulation study of mechanism.
@ast
Na(+) channel mutation that ca ...... simulation study of mechanism.
@en
P2860
P356
P1433
P1476
Na(+) channel mutation that ca ...... simulation study of mechanism.
@en
P2093
Colleen E Clancy
Yoram Rudy
P2860
P304
P356
10.1161/HC1002.105183
P407
P577
2002-03-01T00:00:00Z