In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
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A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signalingAstrocytes: biology and pathologyAstrocytes in multiple sclerosis: a product of their environmentIn vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes.Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.The influence of innate and pre-existing immunity on adenovirus therapyKupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo.Single vs. combination immunotherapeutic strategies for glioma.Gene transfer into rat brain using adenoviral vectors.The synapse and cytolytic machinery of cytotoxic T cells.Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma.Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathologyRapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells.Cytotoxic immunological synapses.CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain.The role of antigen presenting cells in multiple sclerosis.Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics.IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's diseaseCerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND)Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain.Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro.Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cellsInteraction of astrocytes and T cells in physiological and pathological conditionsImmunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.Studying the T Cell-Astrocyte Immune Synapse.One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapsesImmune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactionsCD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brainRespiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cellsNeuroimmunology of central nervous system viral infections: the cells, molecules and mechanisms involved.Gene delivery to the nervous systemTwo-photon imaging of effector T-cell behavior: lessons from a tumor model.The great balancing act: regulation and fate of antiviral T-cell interactionsAdhesions ring: a structural comparison between podosomes and the immune synapse.Inflammation on the mind: visualizing immunity in the central nervous system.Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain.Functional anatomy of T cell activation and synapse formation.
P2860
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P2860
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
In vivo mature immunological s ...... cted astrocytes from the brain
@ast
In vivo mature immunological s ...... cted astrocytes from the brain
@en
type
label
In vivo mature immunological s ...... cted astrocytes from the brain
@ast
In vivo mature immunological s ...... cted astrocytes from the brain
@en
prefLabel
In vivo mature immunological s ...... cted astrocytes from the brain
@ast
In vivo mature immunological s ...... cted astrocytes from the brain
@en
P2093
P2860
P356
P1476
In vivo mature immunological s ...... cted astrocytes from the brain
@en
P2093
Carlos Barcia
Chunyan Liu
Clare E Thomas
David Klatzmann
Gwendalyn D King
James F Curtin
Kolja Wawrowsky
Kurt Kroeger
Maria G Castro
Marianela Candolfi
P2860
P304
P356
10.1084/JEM.20060420
P407
P577
2006-08-21T00:00:00Z