The SH2 domain: versatile signaling module and pharmaceutical target.
about
SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactomeA structure filter for the Eukaryotic Linear Motif Resource.A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor proteinStructure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherinDeciphering of ADP-induced, phosphotyrosine-dependent signaling networks in human platelets by Src-homology 2 region (SH2)-profilingThe Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasisStructural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substratesOncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activitiesSynthetic Protein Scaffolds Based on Peptide Motifs and Cognate Adaptor Domains for Improving Metabolic ProductivityThe Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer CellsFrom modules to medicine: How modular domains and their associated networks can enable personalized medicineActin remodeling by Nck regulates endothelial lumen formationCharacterizing tyrosine phosphorylation signaling in lung cancer using SH2 profilingStructural and energetic aspects of Grb2-SH2 domain-swappingA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainA Tandem SH2 Domain in Transcription Elongation Factor Spt6 Binds the Phosphorylated RNA Polymerase II C-terminal Repeat Domain (CTD)Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavSolution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycleDefining the specificity space of the human SRC homology 2 domainEvolutionary history and functional implications of protein domains and their combinations in eukaryotesSH2 Domains Recognize Contextual Peptide Sequence Information to Determine SelectivityTyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Phylogenetic Profiles Reveal Structural and Functional Determinants of Lipid-bindingFast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.NMR analysis of G7-18NATE, a nonphosphorylated cyclic peptide inhibitor of the Grb7 adapter protein.Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation.Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries.The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages.Identification of Shc Src homology 2 domain-binding peptoid-peptide hybridsEnhanced fusion pore expansion mediated by the trans-acting Endodomain of the reovirus FAST proteins.Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structureIdentification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.Binding of flexible and constrained ligands to the Grb2 SH2 domain: structural effects of ligand preorganization.Cyclic peptide-selenium nanoparticles as drug transporters.The application of modular protein domains in proteomicsTowards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening.Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule microarray.Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors.
P2860
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P2860
The SH2 domain: versatile signaling module and pharmaceutical target.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The SH2 domain: versatile signaling module and pharmaceutical target.
@ast
The SH2 domain: versatile signaling module and pharmaceutical target.
@en
type
label
The SH2 domain: versatile signaling module and pharmaceutical target.
@ast
The SH2 domain: versatile signaling module and pharmaceutical target.
@en
prefLabel
The SH2 domain: versatile signaling module and pharmaceutical target.
@ast
The SH2 domain: versatile signaling module and pharmaceutical target.
@en
P1476
The SH2 domain: versatile signaling module and pharmaceutical target.
@en
P2093
Bruce J Mayer
Kazuya Machida
P356
10.1016/J.BBAPAP.2004.10.005
P407
P577
2004-11-19T00:00:00Z