The selective kappa-opioid receptor agonist U50,488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates.
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Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's diseaseBrain morphometry and the neurobiology of levodopa-induced dyskinesias: current knowledge and future potential for translational pre-clinical neuroimaging studies.L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry.The effects of morphine, naloxone, and κ opioid manipulation on endocrine functioning and social behavior in monogamous titi monkeys (Callicebus cupreus).Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation.Emerging analgesic drugs for Parkinson's disease.Overexpression of GRK6 rescues L-DOPA-induced signaling abnormalities in the dopamine-depleted striatum of hemiparkinsonian rats.Dual κ-agonist/μ-antagonist opioid receptor modulation reduces levodopa-induced dyskinesia and corrects dysregulated striatal changes in the nonhuman primate model of Parkinson disease.
P2860
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P2860
The selective kappa-opioid receptor agonist U50,488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The selective kappa-opioid rec ...... nism in MPTP-treated primates.
@ast
The selective kappa-opioid rec ...... nism in MPTP-treated primates.
@en
type
label
The selective kappa-opioid rec ...... nism in MPTP-treated primates.
@ast
The selective kappa-opioid rec ...... nism in MPTP-treated primates.
@en
prefLabel
The selective kappa-opioid rec ...... nism in MPTP-treated primates.
@ast
The selective kappa-opioid rec ...... nism in MPTP-treated primates.
@en
P2093
P2860
P1476
The selective kappa-opioid rec ...... nism in MPTP-treated primates.
@en
P2093
Daniel M Togasaki
Donato A Di Monte
Heather Cox
J William Langston
Maryka Quik
P2860
P304
P356
10.1016/J.EXPNEUROL.2007.01.024
P407
P577
2007-02-03T00:00:00Z