Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading.
about
Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11IL-6 and IGF-1 Signaling Within and Between Muscle and Bone: How Important is the mTOR Pathway for Bone Metabolism?The relationship between bone mechanical properties and ground reaction forces in normal and hypermuscular miceThe effects of hypermuscularity on shoulder morphology in myostatin-deficient miceJoint dysfunction and functional decline in middle age myostatin null mice.Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.Decreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfectaPolymorphisms of muscle genes are associated with bone mass and incident osteoporotic fractures in Caucasians.Impact of targeted PPARĪ³ disruption on bone remodeling.Transgenic overexpression of bone morphogenetic protein 11 propeptide in skeleton enhances bone formation.The aromatic amino acid tryptophan stimulates skeletal muscle IGF1/p70s6k/mTor signaling in vivo and the expression of myogenic genes in vitro.Immunolocalization of myostatin (GDF-8) following musculoskeletal injury and the effects of exogenous myostatin on muscle and bone healing.Interaction between bone and muscle in older persons with mobility limitationsEnergy Balance, Myostatin, and GILZ: Factors Regulating Adipocyte Differentiation in Belly and Bone.Bone and Muscle Pleiotropy: The Genetics of Associated Traits.Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cellsMyostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle.Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese womenInhibiting myostatin signaling prevents femoral trabecular bone loss and microarchitecture deterioration in diet-induced obese rats.Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury.Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferation in vitro by suppressing Sox-9 expressionMyostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume.Effects of myokines on bone.Myostatin (GDF-8) as a key factor linking muscle mass and bone structureRole of myostatin (GDF-8) signaling in the human anterior cruciate ligamentImpact of glucose-dependent insulinotropic peptide on age-induced bone loss.Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cellsThe osteocyte: an endocrine cell ... and more.A role for myokines in muscle-bone interactionsGDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation.Growth-differentiation factor-8 (GDF-8) in the uterus: its identification and functional significance in the golden hamster.HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy.Myostatin regulates tissue potency and cardiac calcium-handling proteins.Muscle-bone interactions: basic and clinical aspects.Cancellous bone formation response to simulated resistance training during disuse is blunted by concurrent alendronate treatment.Implications of exercise-induced adipo-myokines in bone metabolism.Osteocyte secreted factors inhibit skeletal muscle differentiation.Microgravity Stress: Bone and Connective Tissue.Mechanically loaded myotubes affect osteoclast formation.
P2860
Q24607839-1CD74F78-D459-4E2A-A2B7-2C7FC2063342Q27024703-CBC2216D-C2DB-4752-9363-B2B2CD739619Q28686277-82969362-E07D-425F-B182-F293B4E317FDQ28741035-B322B718-B655-42D7-BA4E-F7BD24B2F18EQ33772285-733C04A6-5CEE-4582-847A-4013BD6E440EQ34485335-A1CB9D8E-6873-4EE8-80A1-4C4791F6ECBEQ34488033-B0CADCFE-415E-46A3-B34E-6004D9849130Q34544274-A0D9A7E5-EB29-4B9B-80E1-A7470941D997Q34570400-AF13AF27-E6BE-4C9C-8C85-F3315DB89189Q35648762-658C2997-91BF-4834-BEC3-D0A98DDC3504Q35655795-EF316ED7-3097-414F-B768-4AA9B70AC9B2Q35733411-87D7A56D-B7B9-45EE-BC7A-EBFC3A4A84CBQ35768143-7E1737EE-0890-4014-9C08-34CC54A53F37Q36100758-3E85E53A-BC61-484C-B1BA-526519D536FDQ36465015-547EBDDA-BD01-4EBA-A75E-21CBD8C3C21FQ36495239-C0715414-B24B-4AAD-9D09-5107899862DCQ36919044-0B6ADE67-4BD7-49CC-ADD3-F228CB6F704EQ36998190-9A9AFB23-5FF2-4973-88CE-E23AA1BFFF99Q37044584-54DBC7A6-11A6-4D4C-947A-C18DB7E2D6CBQ37071670-547C9144-4BF6-453E-BE19-B609F974B419Q37081610-EA5DAEFB-5AAF-44D9-BF3B-4E3C600D08D4Q37081618-DF2952AF-DB24-406E-BC67-53C15D5CA277Q37110746-E17098B5-1027-4CEB-8399-7E8ED5DE4F45Q37112054-DB3DF928-43BC-442A-A266-6D212621B65AQ37121916-EEEC5D13-F169-4AEC-A738-33FB52205C0FQ37128626-DD1B9526-56F5-4C94-B092-3221DCB6036AQ37158691-AEEEC775-1D41-441A-ABE0-4773E96C4532Q37185139-34B351DD-54AB-4094-A954-87B621D28B6EQ37203605-4772DE68-2A11-40DA-B89F-F594F7351088Q37218921-140F0A6E-46D4-4369-9D52-24CB2F712807Q37282297-09A77F38-67EA-40BA-9F4A-B5EB131EACA7Q37465724-FD97998A-38B1-4A05-A6C5-D18E8D305983Q37674663-756BC49E-D077-4078-91B0-CBB586EA36E9Q37709194-857C446E-A81F-4CA4-809B-B46D99A2A64BQ38132696-0CB399A3-E4B8-40F1-8187-1421196F4601Q38335785-C770F33B-09F5-4AEC-8204-5FA915F823F1Q38683297-9F393799-9099-4616-BBAD-330247BB7EC8Q38734896-539F5605-896C-4352-A0C7-EFAB45C0A4EFQ38804471-7142E9DE-AC7A-482A-B03E-AFF8D4F58D88Q39058675-33C969C8-2EC6-40CE-9F76-D3DAEC902A39
P2860
Loss of myostatin (GDF8) function increases osteogenic differentiation of bone marrow-derived mesenchymal stem cells but the osteogenic effect is ablated with unloading.
description
2007 nĆ® lÅ«n-bĆ»n
@nan
2007幓ć®č«ę
@ja
2007幓č«ę
@yue
2007幓č«ę
@zh-hant
2007幓č«ę
@zh-hk
2007幓č«ę
@zh-mo
2007幓č«ę
@zh-tw
2007幓č®ŗę
@wuu
2007幓č®ŗę
@zh
2007幓č®ŗę
@zh-cn
name
Loss of myostatin (GDF8) funct ...... ect is ablated with unloading.
@ast
Loss of myostatin (GDF8) funct ...... ect is ablated with unloading.
@en
type
label
Loss of myostatin (GDF8) funct ...... ect is ablated with unloading.
@ast
Loss of myostatin (GDF8) funct ...... ect is ablated with unloading.
@en
prefLabel
Loss of myostatin (GDF8) funct ...... ect is ablated with unloading.
@ast
Loss of myostatin (GDF8) funct ...... ect is ablated with unloading.
@en
P2093
P2860
P1433
P1476
Loss of myostatin (GDF8) funct ...... fect is ablated with unloading
@en
P2093
C Pennington
K H Wenger
M W Hamrick
P2860
P304
P356
10.1016/J.BONE.2007.02.012
P50
P577
2007-02-23T00:00:00Z