Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. - Wikidata - wikimedia - TriplyDB

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

http://www.wikidata.org/entity/Q36028807

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Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.Common gamma chain cytokines in combinatorial immune strategies against cancer Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs.Mechanistic approaches for the prevention and treatment of chronic GVHD.Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures.Antibody-dependent cell cytotoxicity: immunotherapy strategies enhancing effector NK cells.Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities.Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells.The γ c family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response.Injectable Polymeric Cytokine-Binding Nanowires Are Effective Tissue-Specific Immunomodulators.Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells.Harnessing the power of regulatory T-cells to control autoimmune diabetes: overview and perspective.Phagekines: Screening Binding Properties and Biological Activity of Functional Cytokines Displayed on Phages.Cutting Edge: Differential Fine-Tuning of IL-2- and IL-15-Dependent Functions by Targeting Their Common IL-2/15Rβ/γc Receptor.Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation.IL-2 and Beyond in Cancer Immunotherapy.Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.Immunology: JAK3 inhibition—is it sufficient?Chronic hypoxia in pregnancy affects thymus development in Balb/c mouse offspring via IL2 Signaling.A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination.Mapping Determinants of Cytokine Signaling via Protein Engineering

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P2860

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

http://www.wikidata.org/entity/Q36028807

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2015 nî lūn-bûn

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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

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J.IMMUNI.2015.04.018

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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps

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Daniel H Fowler

http://www.w3.org/2001/XMLSchema#string

Eric O Long

http://www.w3.org/2001/XMLSchema#string

Holbrook Kohrt

http://www.w3.org/2001/XMLSchema#string

Jangsuk Oh

http://www.w3.org/2001/XMLSchema#string

Jason E Foley

http://www.w3.org/2001/XMLSchema#string

K Christopher Garcia

http://www.w3.org/2001/XMLSchema#string

Kipp Weiskopf

http://www.w3.org/2001/XMLSchema#string

Peng Li

http://www.w3.org/2001/XMLSchema#string

Rosanne Spolski

http://www.w3.org/2001/XMLSchema#string

Shoba Amarnath

http://www.w3.org/2001/XMLSchema#string

P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

Th17 and regulatory T cells in mediating and restraining inflammation.

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

Differentiation of effector CD4 T cell populations (*)

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

New insights into the regulation of T cells by gamma(c) family cytokines

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826-838

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10.1016/J.IMMUNI.2015.04.018

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