Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells.
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Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targetsAnti-Insulin Immune Responses Are Detectable in Dogs with Spontaneous DiabetesAdditive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes riskFine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetesBlood and islet phenotypes indicate immunological heterogeneity in type 1 diabetesClonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideIdentification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients.Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patientsHLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions.The multiple origins of Type 1 diabetes.Immunological pathways to β-cell damage in Type 1 diabetes.Progress in immune-based therapies for type 1 diabetes.Signal peptides: new markers in cardiovascular disease?ERAP1 in the pathogenesis of ankylosing spondylitis.Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes.The diagnostic potential of MPT63-derived HLA-A*0201-restricted CD8+ T-cell epitopes for active pulmonary tuberculosis.A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.Genomic evaluation of HLA-DR3+ haplotypes associated with type 1 diabetes.Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials.Autoreactive T cells in type 1 diabetes.Pathophysiological characteristics of preproinsulin-specific CD8+ T cells in subjects with juvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study.The role of polymorphic ERAP1 in autoinflammatory disease
P2860
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P2860
Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Circulating preproinsulin sign ...... e 1 diabetes and kill β-cells.
@ast
Circulating preproinsulin sign ...... e 1 diabetes and kill β-cells.
@en
type
label
Circulating preproinsulin sign ...... e 1 diabetes and kill β-cells.
@ast
Circulating preproinsulin sign ...... e 1 diabetes and kill β-cells.
@en
prefLabel
Circulating preproinsulin sign ...... e 1 diabetes and kill β-cells.
@ast
Circulating preproinsulin sign ...... e 1 diabetes and kill β-cells.
@en
P2093
P2860
P50
P356
P1433
P1476
Circulating preproinsulin sign ...... e 1 diabetes and kill β-cells.
@en
P2093
Ania Skowera
Arnoud de Ru
Guo C Huang
Jake Powrie
Megan Estorninho
Michel G Kester
Richard J Ellis
Robin R Knight
P2860
P304
P356
10.2337/DB11-1520
P407
P577
2012-04-20T00:00:00Z