TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
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Recent advances in understanding the molecular mechanisms of the development and function of Th17 cellsTargeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor ImmunityTGF-β: guardian of T cell functionLymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patientsTGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15TGF-β activation and function in immunity.Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective functionMolecular control of steady-state dendritic cell maturation and immune homeostasis.Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor β receptor signaling.TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cellsThe transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa.Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-β signaling in CD8+ T lymphocytes.Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitisProinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8⁺ T cells responding to infection.A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory ActivityTGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.Transforming growth factor-β signaling is constantly shaping memory T-cell population.Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasisRole of cytokines in thymus- versus peripherally derived-regulatory T cell differentiation and functionTruncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.Clonality, activated antigen-specific CD8(+) T cells, and development of autoimmune cholangitis in dnTGFβRII miceTGF-β receptor maintains CD4 T helper cell identity during chronic viral infectionsInhibition of TGF-β1 signaling promotes central memory T cell differentiation.Suppressing autoimmunity by TGF-β: not just through T(reg) cells.A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling.The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function.SMAD regulatory networks construct a balanced immune system.Homeostatic expansion as a barrier to lymphocyte depletion strategies.The immune suppressive function of transforming growth factor-β (TGF-β) in human diseases.Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs.Two Strikes and You're Out? The Pathogenic Interplay of Coinhibitor Deficiency and Lymphopenia-Induced Proliferation.TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota.Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function.The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function.Impact of Human Mutant TGFβ1/Fc Protein on Memory and Regulatory T Cell Homeostasis Following Lymphodepletion in Nonhuman Primates.
P2860
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P2860
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
@ast
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
@en
type
label
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
@ast
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
@en
prefLabel
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
@ast
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
@en
P2860
P356
P1433
P1476
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation
@en
P2093
Michael J Bevan
P2860
P304
P356
10.1038/NI.2319
P407
P50
P577
2012-05-27T00:00:00Z