Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study

Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study

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http://www.wikidata.org/entity/Q36053935

Q36053935

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Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration Targeting the latent reservoir to achieve functional HIV cure Reversing Gut Damage in HIV Infection: Using Non-Human Primate Models to Instruct Clinical Research CD1d- and MR1-Restricted T Cells in Sepsis Recent developments in human immunodeficiency virus-1 latency research Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs.Perspectives for immunotherapy: which applications might achieve an HIV functional cure?Persistent high mortality in advanced HIV/TB despite appropriate antiretroviral and antitubercular therapy: an emerging challenge Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?Developments in HIV-1 immunotherapy and therapeutic vaccination.Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.Novel factors interfering with human immunodeficiency virus-type 1 replication in vivo and in vitro.Immune interventions in HIV infection.HIV-1 shedding from the female genital tract is associated with increased Th1 cytokines/chemokines that maintain tissue homeostasis and proportions of CD8+FOXP3+ T cells Common gamma chain (γc) cytokines differentially potentiate TNFR family signaling in antigen-activated CD8(+) T cells The role of the thymus in T-cell immune reconstitution after umbilical cord blood transplantation Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.The γδ T-cell receptor repertoire is reconstituted in HIV patients after prolonged antiretroviral therapy.HIV-associated chronic immune activation.Safety and immunological responses to human mesenchymal stem cell therapy in difficult-to-treat HIV-1-infected patients.Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.Single-Cell Characterization of in vitro Migration and Interaction Dynamics of T Cells Expanded with IL-2 and IL-7.Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques Brief Report: Role of Thymic Reconstitution in the Outcome of AIDS-Related PML Sepsis-induced immune dysfunction: can immune therapies reduce mortality?Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation The HIV Cure Research Agenda: The Role of Mathematical Modelling and Cost-Effectiveness Analysis.Supranormal thymic output up to 2 decades after HIV-1 infection Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia.Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies.Interleukin-7 promotes HIV persistence during antiretroviral therapy.Therapeutic advances in the management of chronic hepatitis B infection.Evaluation of TCR repertoire diversity in patients after hematopoietic stem cell transplantation.Altering cell death pathways as an approach to cure HIV infection.The role of cytokines in the establishment, persistence and eradication of the HIV reservoir Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach Early immunologic failure is associated with early mortality among advanced HIV-infected adults initiating antiretroviral therapy with active tuberculosis Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs

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P2860

Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study

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http://www.wikidata.org/entity/Q36053935

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2012 nî lūn-bûn

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2012年论文

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C Goujard

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G Tambussi

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J D Lelièvre

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P2860

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

Quantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoire

Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys.

In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients

Interleukin-2 therapy in patients with HIV infection.

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Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study

about

P2860

P2860

Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study

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