CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
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Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasionOncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discoveryRole of oxidative stress and the microenvironment in breast cancer development and progressionCauses of genome instability: the effect of low dose chemical exposures in modern societyPDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stressProfilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis.Bioinformatic identification of connective tissue growth factor as an osteogenic protein within skeletal muscle.Expression of connective tissue growth factor in male breast cancer: clinicopathologic correlations and prognostic valueHigh EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro modelConvergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade.CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth.Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cellsBreast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition.Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.Inhibition of RUNX2 transcriptional activity blocks the proliferation, migration and invasion of epithelial ovarian carcinoma cells.Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses.Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.Genetic alterations and epigenetic alterations of cancer-associated fibroblasts.Monocyte-derived factors including PLA2G7 induced by macrophage-nasopharyngeal carcinoma cell interaction promote tumor cell invasiveness.miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts.Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and Is Associated with COPD SeverityDeregulated expression of connective tissue growth factor (CTGF/CCN2) is linked to poor outcome in human cancer.Autophagy and cancer metabolism.Value of caveolin-1 in cancer progression and prognosis: Emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review).MicroRNA 375 regulates proliferation and migration of colon cancer cells by suppressing the CTGF-EGFR signaling pathway.Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches.Transarterial embolization combined with RNA interference targeting hypoxia-inducible factor-1α for hepatocellular carcinoma: a preliminary study of rat model.Acriflavine suppresses the growth of human osteosarcoma cells through apoptosis and autophagy.TGF-β Family Signaling in Tumor Suppression and Cancer Progression.Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells.High expression of connective tissue growth factor accelerates dissemination of leukaemia.The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy.Changes in the Secretory Profile of NSCLC-Associated Fibroblasts after Ablative Radiotherapy: Potential Impact on Angiogenesis and Tumor Growth.
P2860
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P2860
CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
CTGF drives autophagy, glycoly ...... ically promoting tumor growth.
@ast
CTGF drives autophagy, glycoly ...... ically promoting tumor growth.
@en
type
label
CTGF drives autophagy, glycoly ...... ically promoting tumor growth.
@ast
CTGF drives autophagy, glycoly ...... ically promoting tumor growth.
@en
prefLabel
CTGF drives autophagy, glycoly ...... ically promoting tumor growth.
@ast
CTGF drives autophagy, glycoly ...... ically promoting tumor growth.
@en
P2093
P2860
P50
P356
P1433
P1476
CTGF drives autophagy, glycoly ...... lically promoting tumor growth
@en
P2093
Claudia Capparelli
Diana Whitaker-Menezes
Federica Sotgia
Michael P Lisanti
Renee Balliet
Richard G Pestell
Timothy G Pestell
P2860
P304
P356
10.4161/CC.20717
P577
2012-06-15T00:00:00Z