Mammalian carboxylesterases: from drug targets to protein therapeutics.
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Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteinsCrystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent SarinEsterase LpEst1 from Lactobacillus plantarum: a novel and atypical member of the αβ hydrolase superfamily of enzymesRational protein design: developing next-generation biological therapeutics and nanobiotechnological toolsButyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behaviorNerve agent hydrolysis activity designed into a human drug metabolism enzymeHorse carboxylesterases: evidence for six CES1 and four families of CES genes on chromosome 3Mammalian carboxylesterase 3: comparative genomics and proteomicsBaboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterasesBovine Carboxylesterases: Evidence for Two CES1 and Five Families of CES Genes on Chromosome 18Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestorStructure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1Carboxylesterases: Dual roles in lipid and pesticide metabolism.Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics studyMolecular mechanisms of fenofibrate-induced metabolic catastrophe and glioblastoma cell death.A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapyCarboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity.Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female micePhospho-ibuprofen (MDC-917) incorporated in nanocarriers: anti-cancer activity in vitro and in vivo.Examination of the carboxylesterase phenotype in human liverInterspecies Differences in the Metabolism of a Multiester Prodrug by CarboxylesterasesRNA Sequencing Quantification of Xenobiotic-Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice.Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.Mammalian carboxylesterase 5: comparative biochemistry and genomics.Polyisoprenylated methylated protein methyl esterase is both sensitive to curcumin and overexpressed in colorectal cancer: implications for chemoprevention and treatment.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).A new class of mammalian carboxylesterase CES6.Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicityCarboxylesterase inhibitors.Streamlined duplex live-dead microplate assay for cultured cells.Carboxylesterases: General detoxifying enzymes.Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancerA highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications.Carboxylate Surrogates Enhance the Antimycobacterial Activity of UDP-Galactopyranose Mutase Probes.Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Multicolor imaging of endoplasmic reticulum-located esterase as a prodrug activation enzyme.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
P2860
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P2860
Mammalian carboxylesterases: from drug targets to protein therapeutics.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Mammalian carboxylesterases: from drug targets to protein therapeutics.
@ast
Mammalian carboxylesterases: from drug targets to protein therapeutics.
@en
type
label
Mammalian carboxylesterases: from drug targets to protein therapeutics.
@ast
Mammalian carboxylesterases: from drug targets to protein therapeutics.
@en
prefLabel
Mammalian carboxylesterases: from drug targets to protein therapeutics.
@ast
Mammalian carboxylesterases: from drug targets to protein therapeutics.
@en
P1433
P1476
Mammalian carboxylesterases: from drug targets to protein therapeutics.
@en
P2093
Philip M Potter
P304
P356
10.1016/S1359-6446(05)03383-0
P577
2005-03-01T00:00:00Z