Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake. - Wikidata - wikimedia - TriplyDB

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.

http://www.wikidata.org/entity/Q36065130

about

Tau Biology and Tau-Directed Therapies for Alzheimer's Disease Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.Glial contributions to neurodegeneration in tauopathies.Immunological memory to hyperphosphorylated tau in asymptomatic individuals.Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset.Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.Tau and neurodegenerative disease: the story so far.Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.Prion-like propagation as a pathogenic principle in frontotemporal dementia.Cellular Models for the Study of Prions.Therapeutic Strategies for Restoring Tau Homeostasis.Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo.Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology.Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology.Tau-based therapies in neurodegeneration: opportunities and challenges.A role for tau in learning, memory and synaptic plasticity.Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.Tau Kinetics in Neurons and the Human Central Nervous System

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Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.

http://www.wikidata.org/entity/Q36065130

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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Distinct Therapeutic Mechanism ...... rsus Blocking Neuronal Uptake.

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Distinct Therapeutic Mechanism ...... rsus Blocking Neuronal Uptake.

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Distinct Therapeutic Mechanism ...... rsus Blocking Neuronal Uptake.

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Distinct Therapeutic Mechanism ...... rsus Blocking Neuronal Uptake.

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Distinct Therapeutic Mechanism ...... rsus Blocking Neuronal Uptake.

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JBC.M115.657924

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Journal of Biological Chemistry

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Distinct Therapeutic Mechanism ...... rsus Blocking Neuronal Uptake.

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Hilda Mirbaha

http://www.w3.org/2001/XMLSchema#string

Hong Jiang

http://www.w3.org/2001/XMLSchema#string

Kristen E Funk

http://www.w3.org/2001/XMLSchema#string

Marc I Diamond

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P2860

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target

Neuropathological stageing of Alzheimer-related changes

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

Signal transduction during Fc receptor-mediated phagocytosis

IgG Fc receptors

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.

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21652-21662

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10.1074/JBC.M115.657924

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35

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290

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David M. Holtzman

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2015-06-30T00:00:00Z

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279729453

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26126828

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