Aurora B kinase phosphorylates and instigates degradation of p53 - Wikidata - wikimedia - TriplyDB

Aurora B kinase phosphorylates and instigates degradation of p53

Aurora B kinase phosphorylates and instigates degradation of p53

http://www.wikidata.org/entity/Q36066322

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Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells Aurora kinases in head and neck cancer GSAASeqSP: a toolset for gene set association analysis of RNA-Seq data Aurora kinases: novel therapy targets in cancers The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer.Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer Vasohibin 2 decreases the cisplatin sensitivity of hepatocarcinoma cell line by downregulating p53.Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer.p53 protects against LPS-induced lung endothelial barrier dysfunction.Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma CSN6 deregulation impairs genome integrity in a COP1-dependent pathway The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.Bimolecular Fluorescence Complementation (BiFC) Assay for Direct Visualization of Protein-Protein Interaction in vivo.Combining dependent P-values with an empirical adaptation of Brown's method.Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth.p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation.p53-Aurora A mitotic feedback loop regulates cell cycle progression and genomic stability.Differential network entropy reveals cancer system hallmarks.COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.FBXW7 is involved in Aurora B degradation.Aurora kinase targeting in lung cancer reduces KRAS-induced transformation.CSN6 positively regulates c-Jun in a MEKK1-dependent manner.CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity.Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer.Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response.Extensive post-translational modification of active and inactivated forms of endogenous p53.CS2164, a novel multi-target inhibitor against tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency.Aurora B: hooking up with cyclin-dependent kinases.Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy.Recommendations for analyzing and reporting TP53 gene variants in the high-throughput sequencing era.

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P2860

Aurora B kinase phosphorylates and instigates degradation of p53

http://www.wikidata.org/entity/Q36066322

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Aurora B kinase phosphorylates and instigates degradation of p53

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Aurora B kinase phosphorylates and instigates degradation of p53

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type

label

Aurora B kinase phosphorylates and instigates degradation of p53

@ast

Aurora B kinase phosphorylates and instigates degradation of p53

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prefLabel

Aurora B kinase phosphorylates and instigates degradation of p53

@ast

Aurora B kinase phosphorylates and instigates degradation of p53

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PNAS.1110287109

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Aurora B kinase phosphorylates and instigates degradation of p53

@en

P2093

Chris P Gully

http://www.w3.org/2001/XMLSchema#string

Chun-Hui Su

http://www.w3.org/2001/XMLSchema#string

Colin Carlock

http://www.w3.org/2001/XMLSchema#string

Daniel Rothenberg

http://www.w3.org/2001/XMLSchema#string

Edward Wang

http://www.w3.org/2001/XMLSchema#string

Enrique Fuentes-Mattei

http://www.w3.org/2001/XMLSchema#string

Fanmao Zhang

http://www.w3.org/2001/XMLSchema#string

Guermarie Velazquez-Torres

http://www.w3.org/2001/XMLSchema#string

Henry P Adams

http://www.w3.org/2001/XMLSchema#string

Hyun Ho Choi

http://www.w3.org/2001/XMLSchema#string

P2860

Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.

Chromosome alignment and segregation regulated by ubiquitination of survivin

Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage

Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

p53 regulates a G2 checkpoint through cyclin B1

Mechanisms of G2 arrest in response to overexpression of p53

WAF1, a potential mediator of p53 tumor suppression

P304

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scholarly article

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10.1073/PNAS.1110287109

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P433

24

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109

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2012-05-18T00:00:00Z

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225050558

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P698

22611192

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P921

phosphorylation

P932

3386093

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