Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism. - Wikidata - wikimedia - TriplyDB

Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.

Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.

http://www.wikidata.org/entity/Q36078767

about

p38 MAPK Signaling in Osteoblast Differentiation Minireview: Challenges and opportunities in development of PPAR agonists Diabetes, bone and glucose-lowering agents: basic biology.Diet and gene interactions influence the skeletal response to polyunsaturated fatty acids Minireview: nuclear receptor regulation of osteoclast and bone remodeling.Impact of oral antidiabetic agents on bone metabolism.G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY.GPR120: A bi-potential mediator to modulate the osteogenic and adipogenic differentiation of BMMSCs The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.Do thiazolidinediones still have a role in treatment of type 2 diabetes mellitus?The future of thiazolidinedione therapy in the management of type 2 diabetes mellitus.Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.Adipose, bone and muscle tissues as new endocrine organs: role of reciprocal regulation for osteoporosis and obesity development.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.Oral anti-diabetic drugs and fracture risk, cut to the bone: safe or dangerous? A narrative review.Agonist-induced activation of human FFA1 receptor signals to extracellular signal-regulated kinase 1 and 2 through Gq- and Gi-coupled signaling cascades.The Role and Future of FFA1 as a Therapeutic Target.GPR40, a free fatty acid receptor, differentially impacts osteoblast behavior depending on differentiation stage and environment.PPARγ signaling and emerging opportunities for improved therapeutics.Rosiglitazone, a PPARγ agonist, ameliorates palmitate-induced insulin resistance and apoptosis in skeletal muscle cells.Diabetes Drug Effects on the Skeleton.Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway.

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P2860

Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.

http://www.wikidata.org/entity/Q36078767

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

@zh-cn

name

Thiazolidinediones induce oste ...... ceptor 40-dependent mechanism.

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Thiazolidinediones induce oste ...... ceptor 40-dependent mechanism.

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type

label

Thiazolidinediones induce oste ...... ceptor 40-dependent mechanism.

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Thiazolidinediones induce oste ...... ceptor 40-dependent mechanism.

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prefLabel

Thiazolidinediones induce oste ...... ceptor 40-dependent mechanism.

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Thiazolidinediones induce oste ...... ceptor 40-dependent mechanism.

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JBC.M111.324814

P1433

Journal of Biological Chemistry

P1476

Thiazolidinediones induce oste ...... eceptor 40-dependent mechanism

@en

P2093

Aleksandra Mieczkowska

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Daniel Chappard

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Michel F Baslé

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P2860

Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1

Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe

Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

PPAR-gamma regulates osteoclastogenesis in mice.

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23517-23526

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scholarly article

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10.1074/JBC.M111.324814

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28

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287

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Guillaume Mabilleau

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2012-05-16T00:00:00Z

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22593579

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G protein-coupled receptor

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3390627

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