Linking folding with aggregation in Alzheimer's beta-amyloid peptides
about
Intrinsically disordered proteins in a physics-based worldForce-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensingλ-Dynamics free energy simulation methodsIntertwined dimeric structure for the SH3 domain of the c-Src tyrosine kinase induced by polyethylene glycol bindingInfluence of preformed Asp23-Lys28 salt bridge on the conformational fluctuations of monomers and dimers of Abeta peptides with implications for rates of fibril formationModulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutationsStructural heterogeneity in familial Alzheimer's disease mutants of amyloid-beta peptides.Membrane environment modulates the pKa values of transmembrane helicesThe Dependence of Amyloid-β Dynamics on Protein Force Fields and Water Models.Energy landscapes of the monomer and dimer of the Alzheimer's peptide Abeta(1-28).Inhibition of beta-amyloid(1-40) Peptide Aggregation and Neurotoxicity by CitratePhysical mechanism for biopolymers to aggregate and maintain in non-equilibrium states.Order through disorder: hyper-mobile C-terminal residues stabilize the folded state of a helical peptide. a molecular dynamics studyConstant pH replica exchange molecular dynamics in biomolecules using a discrete protonation modelPolymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins.Effects of system net charge and electrostatic truncation on all-atom constant pH molecular dynamics.A strategy for reducing gross errors in the generalized Born models of implicit solvation.Intrinsic determinants of Aβ(12-24) pH-dependent self-assembly revealed by combined computational and experimental studies.Constant pH molecular dynamics of proteins in explicit solvent with proton tautomerism.Probing the efficacy of peptide-based inhibitors against acid- and zinc-promoted oligomerization of amyloid-β peptide via single-oligomer spectroscopyPredicting extreme pKa shifts in staphylococcal nuclease mutants with constant pH molecular dynamicsA study of the α-helical intermediate preceding the aggregation of the amino-terminal fragment of the β amyloid peptide (Aβ(1-28))Investigating how peptide length and a pathogenic mutation modify the structural ensemble of amyloid beta monomer.Constant pH Molecular Dynamics Simulations of Nucleic Acids in Explicit Solvent.Autoreactive-Aβ antibodies promote APP β-secretase processing.Adsorption mechanism and collapse propensities of the full-length, monomeric Aβ(1-42) on the surface of a single-walled carbon nanotube: a molecular dynamics simulation study.Charge-leveling and proper treatment of long-range electrostatics in all-atom molecular dynamics at constant pH.Recent advances in implicit solvent-based methods for biomolecular simulationspH-dependent dynamics of complex RNA macromoleculesTowards Accurate Prediction of Protonation Equilibrium of Nucleic Acids.pH-replica exchange molecular dynamics in proteins using a discrete protonation method.Antibody-based therapy in Alzheimer's disease.Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease.CHARMM-GUI 10 years for biomolecular modeling and simulation.Optimization of the GBMV2 implicit solvent force field for accurate simulation of protein conformational equilibria.Probing pH-dependent dissociation of HdeA dimers.The structure of chromophore-grafted amyloid-β(12-28) dimers in the gas-phase: FRET-experiment guided modelling.Constant-pH Molecular Dynamics Study of Kyotorphin in an Explicit Bilayer.pH-sensitive residues in the p19 RNA silencing suppressor protein from carnation Italian ringspot virus affect siRNA binding stability.
P2860
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P2860
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
@ast
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
@en
type
label
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
@ast
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
@en
prefLabel
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
@ast
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
@en
P2860
P356
P1476
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
@en
P2093
Charles L Brooks
Jana Khandogin
P2860
P304
16880-16885
P356
10.1073/PNAS.0703832104
P407
P577
2007-10-17T00:00:00Z